PMID- 27197454
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20181202
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 30
IP  - 1
DP  - 2016 Jan
TI  - [Expression and clinical pathological implications of carbonic anhydrase 9 and P 
      glycoprotein in laryngeal squamous cell carcinoma].
PG  - 42-4
AB  - OBJECTIVE: To identify the difference of CA IX and P-gp expression level between 
      laryngeal squamous cell carcinoma (LSCC) and benign tissues, evaluate the 
      relationship of these two proteins in LSCC, and their correlation with clinical 
      and pathological features. METHOD: Immunohistochemical detection of CA IX and 
      P-gp were performed in 47 cases of LSCC and 20 cases of vocal cord polyps. 
      RESULT: Overexpression of CA IX and P-gp both in LSCC and in vocal cord polyp (P 
      < 0.05) were confirmed, with a correlation between the two proteins in LSCC (r = 
      0.324, P < 0.05). The expression of CA IX was related to clinical staging and 
      lymph node metastasis in LSCC (P < 0.05). While P-gp was related to clinical 
      staging and histological grading in LSCC (P < 0.05). CONCLUSION: The 
      overexpression of CA IX and P-gp may play a role in LSCC progression.
FAU - Chen, Xinwei
AU  - Chen X
FAU - Wang, Fei
AU  - Wang F
FAU - Xie, Fang
AU  - Xie F
FAU - Dong, Pin
AU  - Dong P
FAU - Ying, Xinjiang
AU  - Ying X
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (Antigens, Neoplasm)
RN  - EC 4.2.1.1 (CA9 protein, human)
RN  - EC 4.2.1.1 (Carbonic Anhydrase IX)
RN  - EC 4.2.1.1 (Carbonic Anhydrases)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B/metabolism
MH  - Antigens, Neoplasm/*metabolism
MH  - Carbonic Anhydrase IX
MH  - Carbonic Anhydrases/*metabolism
MH  - Carcinoma, Squamous Cell/metabolism/*pathology
MH  - Humans
MH  - Laryngeal Neoplasms/metabolism/*pathology
MH  - Lymphatic Metastasis
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Polyps/metabolism
MH  - Vocal Cords/metabolism/pathology
EDAT- 2016/05/21 06:00
MHDA- 2016/07/07 06:00
CRDT- 2016/05/21 06:00
PHST- 2016/05/21 06:00 [entrez]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;30(1):42-4.