PMID- 27197857
OWN - NLM
STAT- MEDLINE
DCOM- 20171214
LR  - 20181113
IS  - 1522-1601 (Electronic)
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 121
IP  - 1
DP  - 2016 Jul 1
TI  - Exercise-induced endothelial progenitor cell mobilization is attenuated in 
      impaired glucose tolerance and type 2 diabetes.
PG  - 36-41
LID - 10.1152/japplphysiol.00349.2016 [doi]
AB  - Circulating endothelial progenitor cells (EPCs) contribute to vascular 
      homeostasis and are fewer in those with type 2 diabetes mellitus (T2DM) compared 
      with normal glucose tolerance (NGT), suggesting a link between EPCs and 
      T2DM-associated vasculopathies. The purpose of this study was to assess EPC 
      number and mobilization by acute submaximal exercise in older adults with NGT, 
      impaired glucose tolerance (IGT) or T2DM. We tested the hypothesis that EPC 
      mobilization is lower in IGT compared with NGT and further reduced in older 
      adults with T2DM. Forty-five older (50-75 yr of age) men and women with NGT (n = 
      18), IGT (n = 10), or T2DM (n = 17) were characterized and underwent submaximal 
      aerobic exercise tests with blood sampling for enumeration of vascular 
      endothelial growth factor receptor 2+ (VEGFR2+) cells, CD34+ hematopoetic 
      progenitor cells, and CD34+/VEGFR2+ EPCs by flow cytometry before and after 
      exercise. Basal EPC number was 65 and 61% lower in the IGT and T2DM groups, 
      respectively, compared with the NGT group (P < 0.05). EPC number increased 23% 
      after acute exercise in the NGT group (P < 0.01), but did not change in the IGT 
      or T2DM groups. Before and after exercise, VEGFR2+ cell number was lower in a 
      stepwise manner across the NGT, IGT, and T2DM groups (P < 0.05). Basal CD34+ cell 
      number was lower in the IGT group compared with NGT (P < 0.05), but did not 
      change after exercise in any group. These findings suggest a CD34+/VEGFR2+ EPC 
      mobilization defect in IGT and T2DM that could play a role in the cardiovascular 
      diseases and capillary rarefaction associated with insulin resistance.
FAU - Lutz, Andrew H
AU  - Lutz AH
AD  - Division of Gerontology and Geriatric Medicine, Department of Medicine, 
      University of Maryland School of Medicine and the Baltimore Veterans Affairs 
      Geriatric Research, Education and Clinical Center, Baltimore, Maryland.
FAU - Blumenthal, Jacob B
AU  - Blumenthal JB
AD  - Division of Gerontology and Geriatric Medicine, Department of Medicine, 
      University of Maryland School of Medicine and the Baltimore Veterans Affairs 
      Geriatric Research, Education and Clinical Center, Baltimore, Maryland.
FAU - Landers-Ramos, Rian Q
AU  - Landers-Ramos RQ
AUID- ORCID: 0000-0002-3092-2538
AD  - Division of Gerontology and Geriatric Medicine, Department of Medicine, 
      University of Maryland School of Medicine and the Baltimore Veterans Affairs 
      Geriatric Research, Education and Clinical Center, Baltimore, Maryland.
FAU - Prior, Steven J
AU  - Prior SJ
AUID- ORCID: 0000-0002-4627-6489
AD  - Division of Gerontology and Geriatric Medicine, Department of Medicine, 
      University of Maryland School of Medicine and the Baltimore Veterans Affairs 
      Geriatric Research, Education and Clinical Center, Baltimore, Maryland 
      sprior@grecc.umaryland.edu.
LA  - eng
GR  - I01 CX000730/CX/CSRD VA/United States
GR  - K23 AG040775/AG/NIA NIH HHS/United States
GR  - P30 AG028747/AG/NIA NIH HHS/United States
GR  - T35 DK095737/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160519
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Antigens, CD34)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Antigens, CD34/metabolism
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology
MH  - Endothelial Progenitor Cells/metabolism/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Glucose/metabolism
MH  - Glucose Intolerance/metabolism/*physiopathology
MH  - Glucose Tolerance Test/methods
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Middle Aged
MH  - Vascular Endothelial Growth Factor Receptor-2/metabolism
PMC - PMC4967240
OTO - NOTNLM
OT  - cardiovascular disease
OT  - endothelial progenitor cells
OT  - exercise
OT  - type 2 diabetes mellitus
EDAT- 2016/05/21 06:00
MHDA- 2017/12/15 06:00
PMCR- 2017/07/01
CRDT- 2016/05/21 06:00
PHST- 2016/04/14 00:00 [received]
PHST- 2016/05/16 00:00 [accepted]
PHST- 2016/05/21 06:00 [entrez]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2017/12/15 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - japplphysiol.00349.2016 [pii]
AID - JAPPL-00349-2016 [pii]
AID - 10.1152/japplphysiol.00349.2016 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2016 Jul 1;121(1):36-41. doi: 
      10.1152/japplphysiol.00349.2016. Epub 2016 May 19.