PMID- 27198892
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20220410
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 32
IP  - 8
DP  - 2016 Aug
TI  - Quantitative diffusion-weighted magnetic resonance imaging in the assessment of 
      myocardial fibrosis in hypertrophic cardiomyopathy compared with T1 mapping.
PG  - 1289-97
LID - 10.1007/s10554-016-0909-x [doi]
AB  - To identify myocardial fibrosis in hypertrophic cardiomyopathy (HCM) subjects 
      using quantitative cardiac diffusion-weighted imaging (DWI) and to compare its 
      performance with native T1 mapping and extracellular volume (ECV). Thirty-eight 
      HCM subjects (mean age, 53 +/- 9 years) and 14 normal controls (mean age, 
      51 +/- 8 years) underwent cardiac magnetic resonance imaging (CMRI) on a 3.0T 
      magnetic resonance (MR) machine with DWI, T1 mapping and late gadolinium 
      enhancement (LGE) imaging as the reference standard. The mean apparent diffusion 
      coefficient (ADC), native T1 value and ECV were determined for each subject. 
      Overall, the HCM subjects exhibited an increased native T1 value 
      (1241.04 +/- 78.50 ms), ECV (0.31 +/- 0.03) and ADC (2.36 +/- 0.34 s/mm(2)) compared 
      with the normal controls (1114.60 +/- 37.99 ms, 0.24 +/- 0.04, and 
      1.62 +/- 0.38 s/mm(2), respectively) (p < 0.05). DWI differentiated healthy and 
      fibrotic myocardia with an area under the curve (AUC) of 0.93, while the AUCs of 
      the native T1 values (0.93), (p > 0.05) and ECV (0.94), (p > 0.05) exhibited an 
      equal differentiation ability. Both HCM LGE+ and HCM LGE- subjects had an 
      increased native T1 value, ECV and ADC compared to the normal controls 
      (p < 0.05). HCM LGE+ subjects exhibited an increased ECV (0.31 +/- 0.04) and ADC 
      (2.43 +/- 0.36 s/mm(2)) compared to HCM LGE- subjects (p < 0.05). HCM LGE+ and HCM 
      LGE- subjects had similar native T1 values (1250 +/- 76.36 ms vs. 
      1213.98 +/- 92.30 ms, respectively) (p > 0.05). ADC values were linearly associated 
      with increased ECV (R(2) = 0.36) and native T1 values (R(2) = 0.40) among all 
      subjects. DWI is a feasible alternative to native T1 mapping and ECV for the 
      identification of myocardial fibrosis in patients with HCM. DWI and ECV can 
      quantitatively characterize the extent of fibrosis in HCM LGE+ and HCM LGE- 
      patients.
FAU - Wu, Lian-Ming
AU  - Wu LM
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Chen, Bing-Hua
AU  - Chen BH
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Yao, Qiu-Ying
AU  - Yao QY
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Ou, Yang-Rongzheng
AU  - Ou YR
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Wu, Rui
AU  - Wu R
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Jiang, Meng
AU  - Jiang M
AD  - Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Hu, Jiani
AU  - Hu J
AD  - Department of Radiology, Wayne State University, Detroit, MI, USA.
FAU - An, Dong-Aolei
AU  - An DA
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Xu, Jian-Rong
AU  - Xu JR
AD  - Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China. xujianr@yeah.net.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160519
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/pathology
MH  - Case-Control Studies
MH  - Contrast Media/administration & dosage
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA/administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - DWI
OT  - ECV
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhanced imaging
OT  - Native T1
EDAT- 2016/05/21 06:00
MHDA- 2017/04/25 06:00
CRDT- 2016/05/21 06:00
PHST- 2016/02/19 00:00 [received]
PHST- 2016/05/05 00:00 [accepted]
PHST- 2016/05/21 06:00 [entrez]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
AID - 10.1007/s10554-016-0909-x [pii]
AID - 10.1007/s10554-016-0909-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2016 Aug;32(8):1289-97. doi: 10.1007/s10554-016-0909-x. 
      Epub 2016 May 19.