PMID- 27199662
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160520
LR  - 20200930
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 10
DP  - 2016
TI  - Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network 
      Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and 
      Enforcement of Perirhinal Theta Activity.
PG  - 108
LID - 10.3389/fncel.2016.00108 [doi]
LID - 108
AB  - The neurophysiological processes that can cause theta-to-gamma frequency range 
      (4-80 Hz) network oscillations in the rhinal cortical-hippocampal system and the 
      potential connectivity-based interactions of such forebrain rhythms are a topic 
      of intensive investigation. Here, using selective Channelrhodopsin-2 (ChR2) 
      expression in mouse forebrain glutamatergic cells, we were able to locally, 
      temporally precisely, and reliably induce fast (20-40 Hz) field potential 
      oscillations in hippocampal area CA1 in vitro (at 25 degrees C) and in vivo (i.e., 
      slightly anesthetized NEX-Cre-ChR2 mice). As revealed by pharmacological analyses 
      and patch-clamp recordings from pyramidal cells and GABAergic interneurons in 
      vitro, these light-triggered oscillations can exclusively arise from sustained 
      suprathreshold depolarization (~200 ms or longer) and feedback inhibition of CA1 
      pyramidal neurons, as being mandatory for prototypic pyramidal-interneuron 
      network (P-I) oscillations. Consistently, the oscillations comprised rhythmically 
      occurring population spikes (generated by pyramidal cells) and their frequency 
      increased with increasing spectral power. We further demonstrate that the 
      optogenetically driven CA1 oscillations, which remain stable over repeated 
      evocations, are impaired by the stress hormone corticotropin-releasing factor 
      (CRF, 125 nM) in vitro and, even more remarkably, found that they are accompanied 
      by concurrent states of enforced theta activity in the memory-associated 
      perirhinal cortex (PrC) in vivo. The latter phenomenon most likely derives from 
      neurotransmission via a known, but poorly studied excitatory CA1-->PrC pathway. 
      Collectively, our data provide evidence for the existence of a prototypic 
      (CRF-sensitive) P-I gamma rhythm generator in area CA1 and suggest that CA1 P-I 
      oscillations can rapidly up-regulate theta activity strength in 
      hippocampus-innervated rhinal networks, at least in the PrC.
FAU - Dine, Julien
AU  - Dine J
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; Scientific Core Unit "Electrophysiology and Neuronal Network Dynamics", 
      Max Planck Institute of PsychiatryMunich, Germany.
FAU - Genewsky, Andreas
AU  - Genewsky A
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; Research Group "Neuronal Plasticity", Max Planck Institute of 
      PsychiatryMunich, Germany.
FAU - Hladky, Florian
AU  - Hladky F
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; Scientific Core Unit "Electrophysiology and Neuronal Network Dynamics", 
      Max Planck Institute of PsychiatryMunich, Germany.
FAU - Wotjak, Carsten T
AU  - Wotjak CT
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; Research Group "Neuronal Plasticity", Max Planck Institute of 
      PsychiatryMunich, Germany.
FAU - Deussing, Jan M
AU  - Deussing JM
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; Research Group "Molecular Neurogenetics", Max Planck Institute of 
      PsychiatryMunich, Germany.
FAU - Zieglgansberger, Walter
AU  - Zieglgansberger W
AD  - Max Planck Institute of Psychiatry Munich, Germany.
FAU - Chen, Alon
AU  - Chen A
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; The Ruhman Family Laboratory for Research on the Neurobiology of Stress, 
      Department of Neurobiology, Weizmann Institute of ScienceRehovot, Israel.
FAU - Eder, Matthias
AU  - Eder M
AD  - Max Planck Institute of PsychiatryMunich, Germany; Department "Stress 
      Neurobiology and Neurogenetics", Max Planck Institute of PsychiatryMunich, 
      Germany; Scientific Core Unit "Electrophysiology and Neuronal Network Dynamics", 
      Max Planck Institute of PsychiatryMunich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160426
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
EIN - Front Cell Neurosci. 2016;10:148. PMID: 27375433
PMC - PMC4844905
OTO - NOTNLM
OT  - CA1
OT  - CRF
OT  - gamma
OT  - hippocampus
OT  - optogenetics
OT  - perirhinal cortex
OT  - pyramidal-interneuron network oscillations
OT  - theta
EDAT- 2016/05/21 06:00
MHDA- 2016/05/21 06:01
PMCR- 2016/01/01
CRDT- 2016/05/21 06:00
PHST- 2016/03/23 00:00 [received]
PHST- 2016/04/12 00:00 [accepted]
PHST- 2016/05/21 06:00 [entrez]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2016/05/21 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2016.00108 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2016 Apr 26;10:108. doi: 10.3389/fncel.2016.00108. 
      eCollection 2016.