PMID- 27200379
OWN - NLM
STAT- MEDLINE
DCOM- 20170609
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the 
      Severity of Diabetic Retinopathy in Type 2 Diabetes.
PG  - 3674946
LID - 10.1155/2016/3674946 [doi]
LID - 3674946
AB  - Aims. To assess the association of blood oxygen-transport capacity variables with 
      the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema 
      in patients with type 2 diabetes mellitus (T2DM). Methods. Cross-sectional, 
      case-control study (N = 312) with T2DM: 153 individuals with DR and 159 
      individuals with no DR. Participants were classified according to the severity of 
      DR and the presence of retinal ischemia or macular oedema. Hematological 
      variables were collected by standardized methods. Three logistic models were 
      adjusted to ascertain the association between hematologic variables with the 
      severity of DR and the presence of retinal ischemia or macular oedema. Results. 
      Individuals with severe DR showed significantly lower hemoglobin, hematocrit, and 
      erythrocyte levels compared with those with mild disease and in individuals with 
      retinal ischemia and macular oedema compared with those without these disorders. 
      Hemoglobin was the only factor that showed a significant inverse association with 
      the severity of DR [beta-coefficient = -0.52, P value = 0.003] and retinal 
      ischemia [beta-coefficient = -0.49, P value = 0.001]. Lower erythrocyte level 
      showed a marginally significant association with macular oedema [beta-coefficient 
      = -0.86, P value = 0.055]. Conclusions. In patients with DR, low blood 
      oxygen-transport capacity was associated with more severe DR and the presence of 
      retinal ischemia. Low hemoglobin levels may have a key role in the development 
      and progression of DR.
FAU - Traveset, Alicia
AU  - Traveset A
AD  - Department of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, 
      Spain.
FAU - Rubinat, Esther
AU  - Rubinat E
AD  - Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 
      25198 Lleida, Spain; Institut de Recerca Biomedica de Lleida, University of 
      Lleida, 25198 Lleida, Spain.
FAU - Ortega, Emilio
AU  - Ortega E
AD  - Department of Endocrinology and Nutrition, Institut d'Investigacions Biomediques 
      August Pi Suner, CIBER de Obesidad y Nutricion, Hospital Clinic, 08036 Barcelona, 
      Spain.
FAU - Alcubierre, Nuria
AU  - Alcubierre N
AD  - Institut de Recerca Biomedica de Lleida, University of Lleida, 25198 Lleida, 
      Spain.
FAU - Vazquez, Beatriz
AU  - Vazquez B
AD  - Department of Optometry, University Hospital Arnau de Vilanova, 25198 Lleida, 
      Spain.
FAU - Hernandez, Marta
AU  - Hernandez M
AD  - Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 
      25198 Lleida, Spain.
FAU - Jurjo, Carmen
AU  - Jurjo C
AD  - Department of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, 
      Spain.
FAU - Espinet, Ramon
AU  - Espinet R
AD  - Department of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, 
      Spain.
FAU - Ezpeleta, Juan Antonio
AU  - Ezpeleta JA
AD  - Department of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, 
      Spain.
FAU - Mauricio, Didac
AU  - Mauricio D
AD  - Department of Endocrinology and Nutrition, CIBER of Diabetes and Associated 
      Metabolic Diseases (CIBERDEM), Health Sciences Research Institute and University 
      Hospital Germans Trias i Pujol, 08916 Badalona, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160420
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anemia/*epidemiology/metabolism
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Diabetic Retinopathy/*epidemiology/etiology/metabolism/pathology
MH  - Erythrocyte Count
MH  - Female
MH  - Hematocrit
MH  - Hemoglobins/*metabolism
MH  - Humans
MH  - Ischemia/*epidemiology/etiology/metabolism/pathology
MH  - Macular Edema/*epidemiology/etiology/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Retinal Vessels
MH  - Severity of Illness Index
PMC - PMC4855016
EDAT- 2016/05/21 06:00
MHDA- 2017/06/10 06:00
PMCR- 2016/04/20
CRDT- 2016/05/21 06:00
PHST- 2015/12/19 00:00 [received]
PHST- 2016/03/31 00:00 [accepted]
PHST- 2016/05/21 06:00 [entrez]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2017/06/10 06:00 [medline]
PHST- 2016/04/20 00:00 [pmc-release]
AID - 10.1155/2016/3674946 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:3674946. doi: 10.1155/2016/3674946. Epub 2016 Apr 20.