PMID- 27203127
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20181202
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Linking)
VI  - 61
IP  - 11
DP  - 2016 Jun 7
TI  - Dosimetric comparisons of carbon ion treatment plans for 1D and 2D ripple filters 
      with variable thicknesses.
PG  - 4327-41
LID - 10.1088/0031-9155/61/11/4327 [doi]
AB  - A ripple filter (RiFi)-also called mini-ridge filter-is a passive energy 
      modulator used in particle beam treatments that broadens the Bragg peak (BP) as a 
      function of its maximum thickness. The number of different energies requested 
      from the accelerator can thus be reduced, which significantly reduces the 
      treatment time. A new second generation RiFi with 2D groove shapes was developed 
      using rapid prototyping, which optimizes the beam-modulating material and enables 
      RiFi thicknesses of up to 6 mm. Carbon ion treatment plans were calculated using 
      the standard 1D 3 mm thick RiFi and the new 4 and 6 mm 2D RiFis for spherical 
      planning target volumes (PTVs) in water, eight stage I non-small cell lung cancer 
      cases, four skull base chordoma cases and three prostate cancer cases. TRiP98 was 
      used for treatment planning with facility-specific base data calculated with the 
      Monte Carlo code SHIELD-HIT12A. Dose-volume-histograms, spatial dose 
      distributions and dosimetric indexes were used for plan evaluation. Plan 
      homogeneity and conformity of thinner RiFis were slightly superior to thicker 
      RiFis but satisfactory results were obtained for all RiFis investigated. For the 
      6 mm RiFi, fine structures in the dose distribution caused by the larger energy 
      steps were observed at the PTV edges, in particular for superficial and/or very 
      small PTVs but performances for all RiFis increased with penetration depth due to 
      straggling and scattering effects. Plans with the new RiFi design yielded for the 
      studied cases comparable dosimetric results to the standard RiFi while the 4 and 
      6 mm RiFis lowered the irradiation time by 25-30% and 45-49%, respectively.
FAU - Ringbaek, Toke Printz
AU  - Ringbaek TP
AD  - Technische Hochschule Mittelhessen (THM), Giessen-Friedberg, Germany. Department 
      of Radiotherapy and Radiation Oncology, Philipps-University, Marburg, Germany. 
      Department of Experimental Clinical Oncology, Aarhus University Hospital, 
      Denmark.
FAU - Weber, Uli
AU  - Weber U
FAU - Santiago, Alina
AU  - Santiago A
FAU - Simeonov, Yuri
AU  - Simeonov Y
FAU - Fritz, Peter
AU  - Fritz P
FAU - Kramer, Michael
AU  - Kramer M
FAU - Wittig, Andrea
AU  - Wittig A
FAU - Bassler, Niels
AU  - Bassler N
FAU - Engenhart-Cabillic, Rita
AU  - Engenhart-Cabillic R
FAU - Zink, Klemens
AU  - Zink K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160520
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
RN  - 0 (Carbon Radioisotopes)
SB  - IM
MH  - Carbon Radioisotopes/*therapeutic use
MH  - Female
MH  - Heavy Ion Radiotherapy/*instrumentation/methods
MH  - Humans
MH  - Male
MH  - Neoplasms/*radiotherapy
MH  - *Radiation Dosage
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
EDAT- 2016/05/21 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/05/21 06:00
PHST- 2016/05/21 06:00 [entrez]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
AID - 10.1088/0031-9155/61/11/4327 [doi]
PST - ppublish
SO  - Phys Med Biol. 2016 Jun 7;61(11):4327-41. doi: 10.1088/0031-9155/61/11/4327. Epub 
      2016 May 20.