PMID- 27203172
OWN - NLM
STAT- MEDLINE
DCOM- 20170307
LR  - 20170307
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 71
IP  - 5
DP  - 2016 Oct
TI  - [Use of psychostimulants in a sexual context: Analysis of cases reported to the 
      French network of Addictovigilance Centers].
PG  - 447-455
LID - S0040-5957(16)30012-9 [pii]
LID - 10.1016/j.therap.2016.04.003 [doi]
AB  - The "SLAM" phenomenon is an increasingly popular practice, in Paris and London 
      gay scene, defined by 3 characteristics: injection, sexual party and 
      psychostimulant drugs. The French Medical Agency requested a risk assessment of 
      "SLAM" and more broadly of the use of psychostimulants in a sexual context, by 
      the analysis of complications related to this practice notified to the French 
      Network of Addictovigilance Centers. All cases of complications related to "SLAM" 
      practice, including cases of abuse or dependence, and somatic and psychiatric 
      complications, were analysed. Between January 2008 to December 2013, 51 cases 
      were collected. Users were exclusively men, with a mean age of 40 years, having 
      psychostimulants exposure in a sexual context, mainly in men who have sex with 
      men (MSM) context (100%, n=35). The prevalence of human immunodeficiency virus 
      (HIV) infection was 82% (n=32) with a high level of HIV/hepatitis C virus (HCV) 
      co-infection (50%, n=16). The main psychostimulants reported are synthetic 
      cathinones (89.5%). Cathinones users tended to be polydrug users: 62% also 
      reported use other than psychoactive substances (gamma-butyrolactone [GBL], 
      ketamine, methylenedioxymethamphetamine [MDMA], lysergic acid diethylamide 
      [LSD]...). The main complications were psychiatric disorders in 50% (psychotic 
      symptoms, agitation, anxiety, suicidal ideas or attempt and forensic problems), 
      acute intoxication in 25% (including 3 deaths), dependence and abuse in 17% and 
      infectious complications in 8% (viral seroconversion). Health professionals as 
      well as users should be aware of the physical (cardiovascular) and behavioural 
      (psychic, fast dependence syndrome) toxicity of cathinones. Risk reduction policy 
      must be targeted to the population of MSM with specific interventions both on 
      risky sexual behavior and substance use.
CI  - Copyright (c) 2016 Societe francaise de pharmacologie et de therapeutique. 
      Published by Elsevier Masson SAS. All rights reserved.
FAU - Batisse, Anne
AU  - Batisse A
AD  - Centre d'addictovigilance d'Ile-de-France, Centre GHU Lariboisiere-Fernand-Widal, 
      200, rue du Faubourg-Saint-Denis, 75010 Paris, France. Electronic address: 
      anne.batisse@aphp.fr.
FAU - Peyriere, Helene
AU  - Peyriere H
AD  - Centre d'addictovigilance, hopital Lapeyronie, 34295 Montpellier, France; UMI 
      233/Inserm U1175, 34294 Montpellier, France.
FAU - Eiden, Celine
AU  - Eiden C
AD  - Centre d'addictovigilance, hopital Lapeyronie, 34295 Montpellier, France.
FAU - Courne, Marie-Anne
AU  - Courne MA
AD  - Agence nationale de securite du medicament et des produits de sante, 93285 
      Saint-Denis, France.
FAU - Djezzar, Samira
AU  - Djezzar S
AD  - Centre d'addictovigilance d'Ile-de-France, Centre GHU Lariboisiere-Fernand-Widal, 
      200, rue du Faubourg-Saint-Denis, 75010 Paris, France.
CN  - Reseau francais des centres d'addictovigilance
LA  - fre
PT  - Journal Article
TT  - Usage de psychostimulants dans un contexte sexuel : analyse des cas rapportes au 
      Reseau francais des centres d'addictovigilance. Evaluation des risques lies a la 
      pratique du SLAM.
DEP - 20160426
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adult
MH  - France/epidemiology
MH  - HIV Infections/epidemiology
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychotropic Drugs/*adverse effects
MH  - *Risk-Taking
MH  - Substance-Related Disorders/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cathinones de synthese
OT  - Homme homosexuel
OT  - Male homosexuality
OT  - Sexuality
OT  - Sexualite
OT  - Substance-related disorders
OT  - Synthetic cathinones
OT  - Troubles lies a l'usage de substances
EDAT- 2016/05/21 06:00
MHDA- 2017/03/08 06:00
CRDT- 2016/05/21 06:00
PHST- 2015/11/19 00:00 [received]
PHST- 2016/04/01 00:00 [accepted]
PHST- 2016/05/21 06:00 [pubmed]
PHST- 2017/03/08 06:00 [medline]
PHST- 2016/05/21 06:00 [entrez]
AID - S0040-5957(16)30012-9 [pii]
AID - 10.1016/j.therap.2016.04.003 [doi]
PST - ppublish
SO  - Therapie. 2016 Oct;71(5):447-455. doi: 10.1016/j.therap.2016.04.003. Epub 2016 
      Apr 26.