PMID- 27206415
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20190329
IS  - 1435-1269 (Electronic)
IS  - 0948-6704 (Linking)
VI  - 51
IP  - 1
DP  - 2018 Jan
TI  - Association between cystatin C and heart failure with preserved ejection fraction 
      in elderly Chinese patients.
PG  - 92-97
LID - 10.1007/s00391-016-1058-5 [doi]
AB  - BACKGROUND: Approximately 50 % of patients with heart failure have a preserved 
      ejection fraction (HFpEF). Cystatin C has been reported to be associated with 
      cardiovascular events. This study was carried out to investigate whether 
      cystatin C is associated with cardiac function and cardiac diastolic properties 
      in elderly Chinese HFpEF patients. MATERIAL AND METHODS: A cross-sectional study 
      of 381 elderly Chinese HFpEF patients (81 women, average age 82 +/- 6 years) was 
      conducted. Serum concentrations of cystatin C and the New York Heart Association 
      (NYHA) classification were assessed and early (E) to late (A) transmitral flow 
      velocity ratios (E/A ratio) were measured to assess cardiac diastolic properties. 
      RESULTS: Cystatin C levels, N‑terminal pro brain natriuretic peptide (NT-proBNP) 
      levels and age were significantly correlated to the NYHA class (r = 0.605 P 
      < 0.001, r = 0.333 P < 0.001 and r = 0.254 P < 0.001, respectively). Cystatin C 
      levels, age and body mass index (BMI) were negatively correlated to the E/A ratio 
      (r = -0.224 P = 0.005, r = -0.258 P = 0.001 and r = -0.258 P = 0.003, 
      respectively). The patients with cystatin C concentrations below 1.3 mg/l had a 
      higher E/A ratio compared to those with cystatin C concentrations higher than 
      1.3 mg/l. Cystatin C was also significantly associated with both the NYHA 
      classification and the E/A ratio even after adjustment for the creatinine 
      clearance rate (CCr). CONCLUSION: Both cystatin C and NT-proBNP were found to be 
      correlated to the NYHA classification. Independent of renal function, higher 
      serum concentrations of cystatin C were associated with a worse NYHA 
      classification and abnormal cardiac diastolic properties in elderly Chinese HFpEF 
      patients.
FAU - Xu, C C
AU  - Xu CC
AD  - Department of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth 
      People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China.
FAU - Fu, G X
AU  - Fu GX
AD  - Department of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth 
      People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China.
FAU - Liu, Q Q
AU  - Liu QQ
AD  - Clinical Laboratory, Shanghai Jiaotong University affiliated Shanghai Sixth 
      People's Hospital, Xuhui District, Shanghai, China.
FAU - Zhong, Y
AU  - Zhong Y
AD  - Department of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth 
      People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China. 
      zhongyuansh60@163.com.
LA  - eng
GR  - 1529/Grants from the science project of the Shanghai Jiaotong University 
      affiliated Shanghai Sixth People's Hospital, China/United States
PT  - Journal Article
TT  - Zusammenhang zwischen Cystatin C und Herzinsuffizienz mit erhaltener 
      Ejektionsfraktion bei alteren chinesischen Patienten.
DEP - 20160520
PL  - Germany
TA  - Z Gerontol Geriatr
JT  - Zeitschrift fur Gerontologie und Geriatrie
JID - 9506215
RN  - 0 (Cystatin C)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
EIN - Z Gerontol Geriatr. 2016 Aug;49(6):564. PMID: 27436217
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Flow Velocity/physiology
MH  - Body Mass Index
MH  - China
MH  - Correlation of Data
MH  - Cross-Sectional Studies
MH  - Cystatin C/*blood
MH  - Diastole/physiology
MH  - Female
MH  - Heart Failure/*blood/epidemiology
MH  - Humans
MH  - Male
MH  - Mitral Valve/physiopathology
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Stroke Volume/*physiology
OTO - NOTNLM
OT  - Cystatin C
OT  - Diastolic properties
OT  - Elderly
OT  - Heart failure with preserved ejection fraction
OT  - NYHA classification
EDAT- 2016/05/22 06:00
MHDA- 2019/03/30 06:00
CRDT- 2016/05/22 06:00
PHST- 2015/11/27 00:00 [received]
PHST- 2016/02/26 00:00 [accepted]
PHST- 2016/02/18 00:00 [revised]
PHST- 2016/05/22 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2016/05/22 06:00 [entrez]
AID - 10.1007/s00391-016-1058-5 [pii]
AID - 10.1007/s00391-016-1058-5 [doi]
PST - ppublish
SO  - Z Gerontol Geriatr. 2018 Jan;51(1):92-97. doi: 10.1007/s00391-016-1058-5. Epub 
      2016 May 20.