PMID- 27207679
OWN - NLM
STAT- MEDLINE
DCOM- 20170127
LR  - 20181113
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 37
IP  - 9
DP  - 2016 Sep
TI  - The Rao's Brief Repeatable Battery in the study of cognition in different 
      multiple sclerosis phenotypes: application of normative data in a Serbian 
      population.
PG  - 1475-81
LID - 10.1007/s10072-016-2610-1 [doi]
AB  - Cognitive impairment is prevalent in multiple sclerosis (MS) occurring in 43-72 % 
      of patients with all MS phenotypes. The aim of our study was to assess cognitive 
      performance in different MS subtypes in Serbian population. Rao's Brief 
      Repeatable Battery of neuropsychological tests (BRB-N) was administered to 168 MS 
      patients [37 patients with clinically isolated syndrome (CIS) suggestive of MS, 
      65 with relapsing-remitting MS (RRMS), 31 with secondary progressive MS (SPMS) 
      and 35 patients with primary progressive MS (PPMS)]. The percentage of 
      cognitively impaired patients in our total MS cohort was 58.9 %. Prevalence of 
      cognitive dysfunction was 40.5 % in CIS group, 36.9 % in RRMS, 96.8 % in SPMS, 
      and 85.7 % in PPMS group. Patients in CIS and RRMS groups performed consistently 
      better all tests of the Rao's battery than patients in SPMS and PPMS cohort. CIS 
      and RRMS groups performed consistently better in all tests of the Rao's battery 
      than SPMS and PPMS cohort. Additionally, difference in the performance of any of 
      the BRB-N tests was not found between CIS and RRMS. However, there was a 
      significant difference between SPMS and PPMS patients in the performance on five 
      tests of Rao's battery. Statistical significance (p < 0.05) in favor of PPMS 
      patients was demonstrated for the following tasks: SRT_lts, SRT_cltr, SDMT, 
      SRT_D, SPART_D. Our study demonstrates that cognitive impairment is frequent in 
      all MS phenotypes. Furthermore, we have found that cognitive deficit is most 
      severe and most frequent in SPMS patients, followed by PPMS subjects and then CIS 
      and RRMS patients.
FAU - Dackovic, Jelena
AU  - Dackovic J
AD  - Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University 
      of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia. jelena60@eunet.rs.
FAU - Pekmezovic, Tatjana
AU  - Pekmezovic T
AD  - Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, 
      Serbia.
FAU - Mesaros, Sarlota
AU  - Mesaros S
AD  - Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University 
      of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
FAU - Dujmovic, Irena
AU  - Dujmovic I
AD  - Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University 
      of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
FAU - Stojsavljevic, Nebojsa
AU  - Stojsavljevic N
AD  - Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University 
      of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
FAU - Martinovic, Vanja
AU  - Martinovic V
AD  - Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University 
      of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
FAU - Drulovic, Jelena
AU  - Drulovic J
AD  - Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University 
      of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20160520
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Cognition Disorders/*diagnosis/*etiology
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*classification/*complications
MH  - *Neuropsychological Tests
MH  - Phenotype
MH  - Serbia/epidemiology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Brief Repeatable Battery of neuropsychological tests
OT  - Cognitive impairment
OT  - Depression
OT  - Disability
OT  - Multiple sclerosis
EDAT- 2016/05/22 06:00
MHDA- 2017/01/28 06:00
CRDT- 2016/05/22 06:00
PHST- 2015/12/27 00:00 [received]
PHST- 2016/05/12 00:00 [accepted]
PHST- 2016/05/22 06:00 [entrez]
PHST- 2016/05/22 06:00 [pubmed]
PHST- 2017/01/28 06:00 [medline]
AID - 10.1007/s10072-016-2610-1 [pii]
AID - 10.1007/s10072-016-2610-1 [doi]
PST - ppublish
SO  - Neurol Sci. 2016 Sep;37(9):1475-81. doi: 10.1007/s10072-016-2610-1. Epub 2016 May 
      20.