PMID- 27208878 OWN - NLM STAT- MEDLINE DCOM- 20170619 LR - 20200106 IS - 2299-5684 (Electronic) IS - 1734-1140 (Linking) VI - 68 IP - 4 DP - 2016 Aug TI - A study of chemokines, chemokine receptors and interleukin-6 in patients with panic disorder, personality disorders and their co-morbidity. PG - 756-63 LID - S1734-1140(16)30010-X [pii] LID - 10.1016/j.pharep.2016.03.017 [doi] AB - BACKGROUND: Stress may induce inflammatory changes in the immune system and activate pro-inflammatory cytokines and their receptors by activating the hypothalamic-pituitary-adrenal axis. METHODS: 460 hospitalized patients with panic disorders (PD) and/or personality disorders (P) were studied. The study group comprised subjects with PD, avoidant personality disorder (APD), borderline personality disorder (BPD), obsessive-compulsive personality disorder (OCPD), and concomitant (PD+APD; PD+BPD; PD+OCPD). Each study group consisted of 60 subjects (30 females and 30 males). The control group included 20 females and 20 males without any history of mental disorder. ELISA was used to assess the levels of chemokines: CCL-5/RANTES (regulated on activation, normal T-cell expressed and secreted), CXCL-12/SDF-1 (stromal derived factor), their receptors CXCR-5 (C-C chemokine receptor type-5), CXCR-4 (chemokine C-X-C motif receptor-4), and IL-6. RESULTS: Statistically significant differences in the levels of CCL-5 and CCR-5 were revealed between all study groups. The greatest differences were found between the groups with PD+OCPD and PD+APD. Moreover, concomitance of PD with P significantly increased the level of chemokines and their receptors in all study groups versus the subjects with P alone. CONCLUSIONS: The results of the study show differences between the groups. To be specific, inflammatory markers were more elevated in the study groups than the controls. Therefore, chemokines and chemokine receptors may be used as inflammatory markers in patients with PD co-existent with P to indicate disease severity. PD was found to be a factor in maintaining inflammatory activity in the immune system in patients with P. CI - Copyright (c) 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. FAU - Oglodek, Ewa A AU - Oglodek EA AD - Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland. Electronic address: ewa.oglodek@wp.pl. FAU - Szota, Anna M AU - Szota AM AD - Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland. FAU - Just, Marek J AU - Just MJ AD - Department of General and Endocrine Surgery, Municipal Hospital in Piekary Slaskie, Piekary Slaskie, Poland. FAU - Szromek, Adam R AU - Szromek AR AD - Silesian University of Technology in Gliwice, Gliwice, Poland. FAU - Araszkiewicz, Aleksander AU - Araszkiewicz A AD - Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland. LA - eng PT - Journal Article DEP - 20160412 PL - Switzerland TA - Pharmacol Rep JT - Pharmacological reports : PR JID - 101234999 RN - 0 (Chemokines) RN - 0 (Interleukin-6) RN - 0 (Receptors, Chemokine) SB - IM MH - Adult MH - Case-Control Studies MH - Chemokines/*blood MH - Comorbidity MH - Female MH - Humans MH - Interleukin-6/*blood MH - Male MH - Middle Aged MH - Panic Disorder/*blood/*epidemiology MH - Personality Disorders/*blood/*epidemiology MH - Poland/epidemiology MH - Receptors, Chemokine/*blood OTO - NOTNLM OT - Chemokines OT - Panic disorders OT - Personality disorders EDAT- 2016/05/22 06:00 MHDA- 2017/06/20 06:00 CRDT- 2016/05/22 06:00 PHST- 2015/12/15 00:00 [received] PHST- 2016/03/23 00:00 [revised] PHST- 2016/03/30 00:00 [accepted] PHST- 2016/05/22 06:00 [entrez] PHST- 2016/05/22 06:00 [pubmed] PHST- 2017/06/20 06:00 [medline] AID - S1734-1140(16)30010-X [pii] AID - 10.1016/j.pharep.2016.03.017 [doi] PST - ppublish SO - Pharmacol Rep. 2016 Aug;68(4):756-63. doi: 10.1016/j.pharep.2016.03.017. Epub 2016 Apr 12.