PMID- 27209133
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20220330
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 99
IP  - 8
DP  - 2016 Aug
TI  - Maternal rumen-protected methionine supplementation and its effect on blood and 
      liver biomarkers of energy metabolism, inflammation, and oxidative stress in 
      neonatal Holstein calves.
PG  - 6753-6763
LID - S0022-0302(16)30285-5 [pii]
LID - 10.3168/jds.2016-11018 [doi]
AB  - In nonruminants, nutrition during pregnancy can program offspring development, 
      metabolism, and health in later life. Rumen-protected Met (RPM) supplementation 
      during the prepartum period improves liver function and immune response in dairy 
      cows. Our aim was to investigate the effects of RPM during late pregnancy on 
      blood biomarkers (23 targets) and the liver transcriptome (24 genes) in neonatal 
      calves from cows fed RPM at 0.08% of diet dry matter/d (MET) for the last 21 d 
      before calving or controls (CON). Blood (n=12 calves per diet) was collected at 
      birth before receiving colostrum (baseline), 24 h after receiving colostrum, 14, 
      28, and 50 d (post-weaning) of age. Liver was sampled (n=8 calves per diet) via 
      biopsy on d 4, 14, 28, and 50 of age. Growth and health were not affected by 
      maternal diet. The MET calves had greater overall plasma insulin concentration 
      and lower glucose and ratios of glucose-to-insulin and fatty acids-to-insulin, 
      indicating greater systemic insulin sensitivity. Lower concentration of reactive 
      oxygen metabolites at 14 d of age along with a tendency for lower overall 
      concentration of ceruloplasmin in MET calves indicated a lesser degree of stress. 
      Greater expression on d 4 of fructose-bisphosphatase 1 (FBP1), 
      phosphoenolpyruvate carboxykinase 1 (PCK1), and the facilitated bidirectional 
      glucose transporter SLC2A2 in MET calves indicated alterations in gluconeogenesis 
      and glucose uptake and release. The data agree with the greater expression of the 
      glucocorticoid receptor (GR). Greater expression on d 4 of the insulin receptor 
      (INSR) and insulin-responsive serine/threonine-protein kinase (AKT2) in MET 
      calves indicated alterations in insulin signaling. In that context, the similar 
      expression of sterol regulatory element-binding transcription factor 1 (SREBF1) 
      in CON and MET during the preweaning period followed by the marked upregulation 
      regardless of diet after weaning (d 50) support the idea of changes in hepatic 
      insulin sensitivity during early postnatal life. Expression of carnitine 
      palmitoyltransferase 1A (CPT1A) was overall greater and acyl-CoA oxidase 1 
      (ACOX1) was lower in MET calves, indicating alterations in fatty acid oxidation. 
      Except forkhead box O1 (FOXO1), all genes changed in expression over time. 
      Transcriptome results indicated that calves from MET-supplemented cows underwent 
      a faster maturation of gluconeogenesis and fatty acid oxidation in the liver, 
      which would be advantageous for adapting to the metabolic demands of extrauterine 
      life.
CI  - Copyright (c) 2016 American Dairy Science Association. Published by Elsevier Inc. 
      All rights reserved.
FAU - Jacometo, C B
AU  - Jacometo CB
AD  - NUPEEC (Nucleo de Ensino, Pesquisa e Extensao em Pecuaria), Departamento de 
      Clinicas Veterinaria, Programa de Pos-Graduacao em Biotecnologia, Universidade 
      Federal de Pelotas, 96010-900, Pelotas, RS, Brazil; Mammalian 
      NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional 
      Sciences, University of Illinois, Urbana 61801.
FAU - Zhou, Z
AU  - Zhou Z
AD  - Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of 
      Nutritional Sciences, University of Illinois, Urbana 61801.
FAU - Luchini, D
AU  - Luchini D
AD  - Adisseo NA, Alpharetta, GA, 30022.
FAU - Trevisi, E
AU  - Trevisi E
AD  - Istituto di Zootecnica and Centro di Ricerca Nutrigenomica e 
      Proteomica-PRONUTRIGEN, Facolta di Scienze Agrarie, Alimentari e Ambientali, 
      Universita Cattolica del Sacro Cuore, 29122, Piacenza, Italy.
FAU - Correa, M N
AU  - Correa MN
AD  - NUPEEC (Nucleo de Ensino, Pesquisa e Extensao em Pecuaria), Departamento de 
      Clinicas Veterinaria, Programa de Pos-Graduacao em Biotecnologia, Universidade 
      Federal de Pelotas, 96010-900, Pelotas, RS, Brazil.
FAU - Loor, J J
AU  - Loor JJ
AD  - Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of 
      Nutritional Sciences, University of Illinois, Urbana 61801. Electronic address: 
      jloor@illinois.edu.
LA  - eng
PT  - Journal Article
DEP - 20160518
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Biomarkers)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cattle
MH  - Diet/veterinary
MH  - Energy Metabolism
MH  - Female
MH  - Inflammation/veterinary
MH  - Lactation
MH  - Liver/metabolism
MH  - Methionine/*metabolism
MH  - Milk/metabolism
MH  - Oxidative Stress/genetics
MH  - Rumen/*metabolism
OTO - NOTNLM
OT  - methyl donors
OT  - nutrition
OT  - nutritional programming
OT  - transcriptomics
EDAT- 2016/05/23 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/05/23 06:00
PHST- 2016/02/10 00:00 [received]
PHST- 2016/04/09 00:00 [accepted]
PHST- 2016/05/23 06:00 [entrez]
PHST- 2016/05/23 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
AID - S0022-0302(16)30285-5 [pii]
AID - 10.3168/jds.2016-11018 [doi]
PST - ppublish
SO  - J Dairy Sci. 2016 Aug;99(8):6753-6763. doi: 10.3168/jds.2016-11018. Epub 2016 May 
      18.