PMID- 27209524
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20180111
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 175
IP  - 1-3
DP  - 2016 Aug
TI  - Differential effects of childhood trauma and cannabis use disorders in patients 
      suffering from schizophrenia.
PG  - 161-167
LID - S0920-9964(16)30190-6 [pii]
LID - 10.1016/j.schres.2016.04.042 [doi]
AB  - BACKGROUND: Childhood trauma (CT) and cannabis use are both environmental and 
      modifier risk factors for schizophrenia. However, little is known about how they 
      interact in schizophrenia. We examined the main effect of each of these two 
      environmental factors on the clinical expression of the disease using a large set 
      of variables, and we tested whether and how cannabis and CT interact to influence 
      the course and the presentation of the illness. METHODS: A sample of 366 patients 
      who met the DSM-IV-TR criteria for schizophrenia was recruited through the 
      FACE-SCZ (Fondamental Advanced Centre of Expertise - Schizophrenia) network. 
      Patients completed a large standardized clinical evaluation including Structured 
      Clinical Interview for DSM Disorders-I (SCID-I), Positive and Negative Symptoms 
      Scale (PANSS), Columbia-Suicide Severity Rating Scale (C-SSRS), Global Assessment 
      of Functioning (GAF), Short-Quality of Life-18 (S-QoL-18), and Medication 
      Adherence Rating Scale (MARS). We assessed CT with the Childhood Trauma 
      Questionnaire and cannabis status with SCID-I. RESULTS: CT significantly 
      predicted the number of hospitalizations, GAF, and S-QoL-18 scores, as well as 
      the PANSS total, positive, excitement, and emotional distress scores. Cannabis 
      use disorders significantly predicted age of onset, and MARS. There was no 
      significant interaction between CT and cannabis use disorders. However, we found 
      evidence of a correlation between these two risk factors. CONCLUSIONS: CT and 
      cannabis both have differential deleterious effects on clinical and functional 
      outcomes in patients with schizophrenia. Our results highlight the need to 
      systematically assess the presence of these risk factors and adopt suitable 
      therapeutic interventions.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Baudin, G
AU  - Baudin G
AD  - Fondation FondaMental, Creteil F94000, France; INSERM U955, Equipe de Psychiatrie 
      Translationnelle, Creteil F94000, France; AP-HP, DHU Pe-PSY, Pole de Psychiatrie 
      des Hopitaux Universitaires H Mondor, Creteil F94000, France; Universite 
      Francois-Rabelais de Tours, PAV EA 2114, Tours F37000, France.
FAU - Godin, O
AU  - Godin O
AD  - Fondation FondaMental, Creteil F94000, France; Sorbonne Universites, UPMC Univ 
      Paris 06, INSERM, Institut Pierre Louis d'epidemiologie et de Sante Publique 
      (IPLESP UMRS 1136), F75013 Paris, France.
FAU - Lajnef, M
AU  - Lajnef M
AD  - INSERM U955, Equipe de Psychiatrie Translationnelle, Creteil F94000, France.
FAU - Aouizerate, B
AU  - Aouizerate B
AD  - Fondation FondaMental, Creteil F94000, France; Centre Hospitalier Charles 
      Perrens, F-33076, Bordeaux, France; Universite de Bordeaux, France; Inserm, 
      Neurocentre Magendie, Physiopathologie de la Plasticite Neuronale, U862, F-33000, 
      Bordeaux, France.
FAU - Berna, F
AU  - Berna F
AD  - Fondation FondaMental, Creteil F94000, France; Hopitaux Universitaires de 
      Strasbourg, Universite de Strasbourg, INSERM U1114, Federation de Medecine 
      Translationnelle de Strasbourg, Strasbourg, France.
FAU - Brunel, L
AU  - Brunel L
AD  - Fondation FondaMental, Creteil F94000, France; INSERM U955, Equipe de Psychiatrie 
      Translationnelle, Creteil F94000, France; AP-HP, DHU Pe-PSY, Pole de Psychiatrie 
      des Hopitaux Universitaires H Mondor, Creteil F94000, France; Universite 
      Paris-Est Creteil F94000, France.
FAU - Capdevielle, D
AU  - Capdevielle D
AD  - Fondation FondaMental, Creteil F94000, France; Service Universitaire de 
      Psychiatrie Adulte, Hopital la Colombiere, CHRU Montpellier, Universite 
      Montpellier 1, Inserm 1061, Montpellier, France.
FAU - Chereau, I
AU  - Chereau I
AD  - Fondation FondaMental, Creteil F94000, France; CMP B, CHU, EA 7280 Faculte de 
      Medecine, Universite d'Auvergne, BP 69, 63003 Clermont-Ferrand Cedex 1, France.
FAU - Dorey, J M
AU  - Dorey JM
AD  - Fondation FondaMental, Creteil F94000, France; Universite Claude Bernard Lyon 1, 
      Centre Hospitalier Le Vinatier, Pole Est BP 300 39, 95 bd Pinel, 69678 Bron 
      Cedex, France.
FAU - Dubertret, C
AU  - Dubertret C
AD  - Fondation FondaMental, Creteil F94000, France; AP-HP, Department of Psychiatry, 
      Louis Mourier Hospital, Colombes, Inserm U894, Universite Paris Diderot, Sorbonne 
      Paris Cite, Faculte de Medecine, France.
FAU - Dubreucq, J
AU  - Dubreucq J
AD  - Fondation FondaMental, Creteil F94000, France; Centre Referent de Rehabilitation 
      Psychosociale, CH Alpes Isere, Grenoble, France.
FAU - Faget, C
AU  - Faget C
AD  - Fondation FondaMental, Creteil F94000, France; Assistance Publique des Hopitaux 
      de Marseille (AP-HM), Pole Universitaire de Psychiatrie, Marseille, France.
FAU - Fond, G
AU  - Fond G
AD  - Fondation FondaMental, Creteil F94000, France; INSERM U955, Equipe de Psychiatrie 
      Translationnelle, Creteil F94000, France; AP-HP, DHU Pe-PSY, Pole de Psychiatrie 
      des Hopitaux Universitaires H Mondor, Creteil F94000, France; Universite 
      Paris-Est Creteil F94000, France.
FAU - Gabayet, F
AU  - Gabayet F
AD  - Fondation FondaMental, Creteil F94000, France; Centre Referent de Rehabilitation 
      Psychosociale, CH Alpes Isere, Grenoble, France.
FAU - Laouamri, H
AU  - Laouamri H
AD  - Fondation FondaMental, Creteil F94000, France.
FAU - Lancon, C
AU  - Lancon C
AD  - Fondation FondaMental, Creteil F94000, France; Assistance Publique des Hopitaux 
      de Marseille (AP-HM), Pole Universitaire de Psychiatrie, Marseille, France.
FAU - Le Strat, Y
AU  - Le Strat Y
AD  - Fondation FondaMental, Creteil F94000, France; AP-HP, Department of Psychiatry, 
      Louis Mourier Hospital, Colombes, Inserm U894, Universite Paris Diderot, Sorbonne 
      Paris Cite, Faculte de Medecine, France.
FAU - Tronche, A M
AU  - Tronche AM
AD  - Fondation FondaMental, Creteil F94000, France; CMP B, CHU, EA 7280 Faculte de 
      Medecine, Universite d'Auvergne, BP 69, 63003 Clermont-Ferrand Cedex 1, France.
FAU - Misdrahi, D
AU  - Misdrahi D
AD  - Fondation FondaMental, Creteil F94000, France; Universite de Bordeaux, France; 
      Hopitaux Universitaires de Strasbourg, Universite de Strasbourg, INSERM U1114, 
      Federation de Medecine Translationnelle de Strasbourg, Strasbourg, France; CNRS 
      UMR 5287-INCIA, France.
FAU - Rey, R
AU  - Rey R
AD  - Fondation FondaMental, Creteil F94000, France; Universite Claude Bernard Lyon 1, 
      Centre Hospitalier Le Vinatier, Pole Est BP 300 39, 95 bd Pinel, 69678 Bron 
      Cedex, France.
FAU - Passerieux, C
AU  - Passerieux C
AD  - Fondation FondaMental, Creteil F94000, France; Service de Psychiatrie d'Adulte, 
      Centre Hospitalier de Versailles, UFR des Sciences de la Sante Simone Veil, 
      Universite Versailles Saint-Quentin en Yvelines, Versailles, France.
FAU - Schandrin, A
AU  - Schandrin A
AD  - Fondation FondaMental, Creteil F94000, France; Service Universitaire de 
      Psychiatrie Adulte, Hopital la Colombiere, CHRU Montpellier, Universite 
      Montpellier 1, Inserm 1061, Montpellier, France.
FAU - Urbach, M
AU  - Urbach M
AD  - Fondation FondaMental, Creteil F94000, France; Service de Psychiatrie d'Adulte, 
      Centre Hospitalier de Versailles, UFR des Sciences de la Sante Simone Veil, 
      Universite Versailles Saint-Quentin en Yvelines, Versailles, France.
FAU - Vidalhet, P
AU  - Vidalhet P
AD  - Hopitaux Universitaires de Strasbourg, Universite de Strasbourg, INSERM U1114, 
      Federation de Medecine Translationnelle de Strasbourg, Strasbourg, France.
FAU - Llorca, P M
AU  - Llorca PM
AD  - Fondation FondaMental, Creteil F94000, France; CMP B, CHU, EA 7280 Faculte de 
      Medecine, Universite d'Auvergne, BP 69, 63003 Clermont-Ferrand Cedex 1, France.
FAU - Schurhoff, F
AU  - Schurhoff F
AD  - Fondation FondaMental, Creteil F94000, France; INSERM U955, Equipe de Psychiatrie 
      Translationnelle, Creteil F94000, France; AP-HP, DHU Pe-PSY, Pole de Psychiatrie 
      des Hopitaux Universitaires H Mondor, Creteil F94000, France; Universite 
      Paris-Est Creteil F94000, France. Electronic address: franck.schurhoff@inserm.fr.
CN  - FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) 
      Collaborators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20160518
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - *Adult Survivors of Child Adverse Events/psychology
MH  - Age of Onset
MH  - Female
MH  - Humans
MH  - Male
MH  - Marijuana Abuse/*complications/*psychology
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/psychology
MH  - Schizophrenia/*complications
MH  - Schizophrenic Psychology
MH  - Stress, Psychological/complications
OTO - NOTNLM
OT  - Cannabis use disorder
OT  - Childhood trauma
OT  - Schizophrenia
EDAT- 2016/05/23 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/05/23 06:00
PHST- 2015/11/06 00:00 [received]
PHST- 2016/04/20 00:00 [revised]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/23 06:00 [entrez]
PHST- 2016/05/23 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
AID - S0920-9964(16)30190-6 [pii]
AID - 10.1016/j.schres.2016.04.042 [doi]
PST - ppublish
SO  - Schizophr Res. 2016 Aug;175(1-3):161-167. doi: 10.1016/j.schres.2016.04.042. Epub 
      2016 May 18.