PMID- 27210450 OWN - NLM STAT- MEDLINE DCOM- 20170627 LR - 20181202 IS - 1532-6578 (Electronic) IS - 1062-0303 (Linking) VI - 34 IP - 2 DP - 2016 Jun TI - Clopidogrel loading dose in the management of ST elevation myocardial infarction: Still a debate! PG - 44-6 LID - S1062-0303(16)00002-9 [pii] LID - 10.1016/j.jvn.2016.01.001 [doi] AB - Clopidogrel as a potent antiplatelet agent is administered in patients with ST elevation myocardial infarction (STEMI). The efficacy and safety of 2 clopidogrel loading regimen (300 mg vs 600 mg) in STEMI patients undergoing a primary percutaneous coronary intervention is still under investigation. The purpose of this article is to highlight current knowledge and guidelines regarding clopidogrel loading dose and also time of administration in STEMI setting and before primary percutaneous coronary intervention. CI - Copyright (c) 2016 Society for Vascular Nursing, Inc. Published by Elsevier Inc. All rights reserved. FAU - Alyasin, Najmeh AU - Alyasin N AD - Coronary Care Unit, Department of Cardiology, The Canberra Hospital, Garran, Australian Capital Territory, Australia. Electronic address: nalyasin@yahoo.com. LA - eng PT - Journal Article PL - United States TA - J Vasc Nurs JT - Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing JID - 9014475 RN - 0 (Platelet Aggregation Inhibitors) RN - A74586SNO7 (Clopidogrel) RN - OM90ZUW7M1 (Ticlopidine) CIN - J Vasc Nurs. 2017 Mar;35(1):3. PMID: 28224949 MH - Clopidogrel MH - Guideline Adherence/*standards MH - Humans MH - Platelet Aggregation Inhibitors/*therapeutic use MH - ST Elevation Myocardial Infarction/*drug therapy/therapy MH - Ticlopidine/administration & dosage/*analogs & derivatives EDAT- 2016/05/24 06:00 MHDA- 2017/06/28 06:00 CRDT- 2016/05/24 06:00 PHST- 2015/10/27 00:00 [received] PHST- 2016/01/10 00:00 [revised] PHST- 2016/01/10 00:00 [accepted] PHST- 2016/05/24 06:00 [entrez] PHST- 2016/05/24 06:00 [pubmed] PHST- 2017/06/28 06:00 [medline] AID - S1062-0303(16)00002-9 [pii] AID - 10.1016/j.jvn.2016.01.001 [doi] PST - ppublish SO - J Vasc Nurs. 2016 Jun;34(2):44-6. doi: 10.1016/j.jvn.2016.01.001.