PMID- 27211292
OWN - NLM
STAT- MEDLINE
DCOM- 20170615
LR  - 20170615
IS  - 1466-447X (Electronic)
IS  - 0264-0414 (Linking)
VI  - 35
IP  - 7
DP  - 2017 Apr
TI  - The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in 
      two independent sample groups.
PG  - 655-662
LID - 10.1080/02640414.2016.1183806 [doi]
AB  - Matrix metalloproteinase-3 (MMP3) is a mediator of matrix remodelling and a 
      proposed susceptibility locus in the genetic profile of musculoskeletal soft 
      tissue injuries. Therefore, this study aimed to validate the MMP3 gene as a risk 
      marker for these injuries by conducting a case control genetic association study 
      in two independent samples groups. Three previously investigated MMP3 variants 
      (rs679620, rs591058 and rs650108) in addition to the functional promoter variant 
      (rs3025058) were genotyped in 195 Australian control participants and 79 
      Australian individuals with chronic Achilles tendinopathy. Similarly, 234 South 
      African individuals with acute anterior cruciate ligament ruptures and 232 
      matched control participants were also analysed. Based on high linkage with the 
      previously associated MMP3 variant rs679620, rs3025058 was inferred and found to 
      be associated with increased risk for Achilles tendinopathy within the South 
      African group (P = 0.012; OR: 2.88; 95% CI: 1.4 to 6.1). Lastly, the 6A-G-C-G 
      haplotype, constructed from the investigated variants, was significantly 
      associated with reduced risk for Achilles tendinopathy (29% CON vs. 20% TEN, 
      P = 0.037) in the Australian group. In conclusion, a signal surrounding MMP3 is 
      apparent with respect to Achilles tendinopathy. However, whether the investigated 
      variants are contributing to injury susceptibility or whether they are merely 
      linked to the risk conferring variants mapping elsewhere within the MMP gene 
      cluster on chromosome 11, still requires refining.
FAU - Gibbon, A
AU  - Gibbon A
AD  - a Division of Exercise Science and Sports Medicine, Department of Human Biology, 
      Faculty of Health Sciences , University of Cape Town , Cape Town , South Africa.
FAU - Hobbs, H
AU  - Hobbs H
AD  - b Sports Science Orthopaedic Clinic , Sports Science Institute of South Africa , 
      Cape Town , South Africa.
FAU - van der Merwe, W
AU  - van der Merwe W
AD  - b Sports Science Orthopaedic Clinic , Sports Science Institute of South Africa , 
      Cape Town , South Africa.
FAU - Raleigh, S M
AU  - Raleigh SM
AD  - c Centre for Physical Activity and Chronic Disease, Institute of Health and 
      Wellbeing, School of Health , University of Northampton , Northampton , UK.
FAU - Cook, J
AU  - Cook J
AD  - d School of Primary Health Care, Faculty of Medicine, Nursing and Health Sciences 
      , Monash University , Melbourne , Australia.
FAU - Handley, C J
AU  - Handley CJ
AD  - e Department of Physiology, Anatomy and Microbiology , La Trobe University , 
      Melbourne , Australia.
FAU - Posthumus, M
AU  - Posthumus M
AD  - a Division of Exercise Science and Sports Medicine, Department of Human Biology, 
      Faculty of Health Sciences , University of Cape Town , Cape Town , South Africa.
FAU - Collins, M
AU  - Collins M
AD  - a Division of Exercise Science and Sports Medicine, Department of Human Biology, 
      Faculty of Health Sciences , University of Cape Town , Cape Town , South Africa.
FAU - September, A V
AU  - September AV
AD  - a Division of Exercise Science and Sports Medicine, Department of Human Biology, 
      Faculty of Health Sciences , University of Cape Town , Cape Town , South Africa.
LA  - eng
PT  - Journal Article
DEP - 20160521
PL  - England
TA  - J Sports Sci
JT  - Journal of sports sciences
JID - 8405364
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Achilles Tendon
MH  - Adult
MH  - Anterior Cruciate Ligament
MH  - Anterior Cruciate Ligament Injuries/*genetics
MH  - Australia
MH  - Chromosomes, Human, Pair 11
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - *Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Soft Tissue Injuries/*genetics
MH  - South Africa
MH  - Tendinopathy/*genetics
OTO - NOTNLM
OT  - Musculoskeletal soft tissue injuries
OT  - genetics association studies
OT  - matrix metalloproteinase-3
EDAT- 2016/05/24 06:00
MHDA- 2017/06/16 06:00
CRDT- 2016/05/24 06:00
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/06/16 06:00 [medline]
PHST- 2016/05/24 06:00 [entrez]
AID - 10.1080/02640414.2016.1183806 [doi]
PST - ppublish
SO  - J Sports Sci. 2017 Apr;35(7):655-662. doi: 10.1080/02640414.2016.1183806. Epub 
      2016 May 21.