PMID- 27211806
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20170817
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 34
IP  - 8
DP  - 2016 Aug
TI  - Comparison of serum sodium levels measured by blood gas analyzer and biochemistry 
      autoanalyzer in patients with hyponatremia, eunatremia, and hypernatremia.
PG  - 1473-9
LID - S0735-6757(16)30087-0 [pii]
LID - 10.1016/j.ajem.2016.04.037 [doi]
AB  - BACKGROUND: Blood gas analyzer (BGA) electrolyte measurements are frequently used 
      in emergency departments (EDs) pending biochemistry laboratory autoanalyzer (BLA) 
      results. There is lack of data in the literature in terms of agreement of these 2 
      measurement methods of sodium. We aimed to comprehensively evaluate the agreement 
      in hyponatremia, eunatremia, and hypernatremia groups. METHODS: Retrospectively, 
      adult subjects who presented to ED of a tertiary care teaching hospital and had 
      simultaneous BGA and BLA results were included in the study. Blood pairs were 
      grouped into hyponatremia, eunatremia, and hypernatremia according to BLA 
      results. Agreement of sodium measurements between the methods were evaluated by 
      Bland-Altman plots and Passing and Bablok regression analysis. RESULTS: A total 
      of 2557 blood pairs (1326 males [51.8%]) were included. Median age of the 
      patients was 66 years (18-103). The numbers of patients with hyponatremia, 
      eunatremia, and hypernatremia were 487 (19%), 1943 (76%), and 127 (5%), 
      respectively. The minimum and maximum serum sodium levels measured by 
      biochemistry analyzer were 106 and 171 mmol/L, respectively. The Pearson linear 
      correlation coefficient between BGA and BLA for sodium measurements were 0.574, 
      0.358, and 0.562 in hyponatremia, eunatremia, and hypernatremia groups, 
      respectively. The absolute mean difference for the 3 groups was greater than 4 
      mmol/L. Biochemistry laboratory autoanalyzer tended to measure serum sodium 
      higher than BGA in all sodium groups. Passing and Bablok regression analysis 
      showed significant differences between the 2 methods in all sodium groups. 
      CONCLUSION: This is the first comprehensive evaluation of agreement between BGA 
      and BLA in distinct sodium groups. Significant differences should be taken into 
      account when these patients are managed in the ED.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Solak, Yalcin
AU  - Solak Y
AD  - Division of Nephrology, Department of Internal Medicine, Sakarya Research and 
      Training Hospital, Sakarya, Turkey. Electronic address: yalcinsolakmd@gmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160429
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Gas Analysis/instrumentation
MH  - *Emergency Service, Hospital
MH  - Female
MH  - Humans
MH  - Hypernatremia/*blood
MH  - Hyponatremia/*blood
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sodium/*blood
MH  - Young Adult
EDAT- 2016/05/24 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/05/24 06:00
PHST- 2016/04/01 00:00 [received]
PHST- 2016/04/25 00:00 [revised]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/24 06:00 [entrez]
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
AID - S0735-6757(16)30087-0 [pii]
AID - 10.1016/j.ajem.2016.04.037 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2016 Aug;34(8):1473-9. doi: 10.1016/j.ajem.2016.04.037. Epub 2016 
      Apr 29.