PMID- 27212193
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20201209
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 41
IP  - 10
DP  - 2016 Oct
TI  - Antibacterial Activity of Silver Nanoparticle-Loaded Soft Contact Lens Materials: 
      The Effect of Monomer Composition.
PG  - 1286-1293
AB  - PURPOSE: In the present work, the effect of monomer composition on silver 
      nanoparticles' (SNPs) binding capacity of hydrogels was investigated and their 
      antibacterial efficacy was evaluated. MATERIALS AND METHODS: Three series of 
      poly-hydroxyethyl methacrylate (HEMA) hydrogels were prepared using methacrylic 
      acid (MAA), methacrylamide (MAAM), and 4-vinylpyridine (4VP) as co-monomers, and 
      ethylene glycol dimethacrylate (EGDMA) as cross-linker. SNPs binding capacity of 
      hydrogels was evaluated in different concentrations (2, 10, and 20 ppm). In vitro 
      antibacterial activity of SNP-loaded hydrogels was studied against Pseudomonas 
      aeruginosa (P. aeruginosa) isolated from patients' eyes. Then, inhibitory effect 
      of hydrogels in biofilm formation was evaluated in the presence of Staphylococcus 
      epidermidis (S. epidermidis) (DSMZ 3270). RESULTS: Our data indicated that 
      poly(HEMA-co-MAA-co-EGDMA) had superior binding affinity for SNPs in comparison 
      with other hydrogels. All SNP-loaded hydrogels demonstrated excellent 
      antimicrobial effects at all times against P. aeruginosa and S. epidermidis after 
      soaking in 10 and 20 ppm SNP suspensions. Scanning electron microscope (SEM) 
      images revealed excellent inhibitory effect of SNPs against biofilm formation on 
      the surface of the hydrogels. CONCLUSIONS: This study indicated the effect of 
      monomer compositions in SNP loading capacity of poly(HEMA) hydrogels and 
      antibacterial efficacy of SNP-loaded hydrogels against P. aeruginosa and S. 
      epidermidis, but further in vivo evaluation is necessary.
FAU - Shayani Rad, Maryam
AU  - Shayani Rad M
AD  - a Student Research Committee (SRC ), Mashhad University of Medical Sciences , 
      Mashhad , Iran.
AD  - b Targeted Drug Delivery Research Center, School of Pharmacy , Mashhad University 
      of Medical Sciences , Mashhad , Iran.
FAU - Khameneh, Bahman
AU  - Khameneh B
AD  - c Department of Pharmaceutical Control , Mashhad University of Medical Sciences , 
      Mashhad , Iran.
FAU - Sabeti, Zahra
AU  - Sabeti Z
AD  - d Biotechnology Research Center, School of Pharmacy , Mashhad University of 
      Medical Sciences , Mashhad , Iran.
FAU - Mohajeri, Seyed Ahmad
AU  - Mohajeri SA
AD  - b Targeted Drug Delivery Research Center, School of Pharmacy , Mashhad University 
      of Medical Sciences , Mashhad , Iran.
FAU - Fazly Bazzaz, Bibi Sedigheh
AU  - Fazly Bazzaz BS
AD  - d Biotechnology Research Center, School of Pharmacy , Mashhad University of 
      Medical Sciences , Mashhad , Iran.
LA  - eng
PT  - Journal Article
DEP - 20160521
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Anti-Bacterial Agents)
RN  - 3M4G523W1G (Silver)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - *Contact Lenses, Hydrophilic
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Humans
MH  - *Nanoparticles
MH  - Pseudomonas aeruginosa/*drug effects
MH  - Silver/*pharmacology
MH  - Staphylococcus epidermidis/*drug effects
OTO - NOTNLM
OT  - Antimicrobial effect
OT  - biofilm
OT  - hydrogels
OT  - poly-hydroxyethyl methacrylate
OT  - silver nanoparticles
EDAT- 2016/05/24 06:00
MHDA- 2017/10/20 06:00
CRDT- 2016/05/24 06:00
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
PHST- 2016/05/24 06:00 [entrez]
AID - 10.3109/02713683.2015.1123726 [doi]
PST - ppublish
SO  - Curr Eye Res. 2016 Oct;41(10):1286-1293. doi: 10.3109/02713683.2015.1123726. Epub 
      2016 May 21.