PMID- 27212590
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20181202
IS  - 1743-9159 (Electronic)
IS  - 1743-9159 (Linking)
VI  - 31
DP  - 2016 Jul
TI  - Parathyroid carcinoma and atypical parathyroid neoplasms in MEN1 patients; A 
      clinico-pathologic challenge. The MD Anderson case series and review of the 
      literature.
PG  - 10-6
LID - S1743-9191(16)30118-2 [pii]
LID - 10.1016/j.ijsu.2016.05.035 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a genetic disorder 
      characterized by usually benign tumors of the parathyroid glands, pancreatic 
      islet cells, and anterior pituitary. Hyperparathyroidism (HPT) occurs in 90% of 
      MEN1 patients. In rare cases, it is associated with parathyroid carcinoma (PC) or 
      atypical parathyroid neoplasm (APN). We present a cohort of 3 such patients. 
      METHODS: We performed a retrospective review of our institution's MEN1 database 
      to identify patients who underwent operations for HPT and had a histopathologic 
      diagnosis of PC or APN. Clinical features, genetics, and outcomes were 
      summarized. RESULTS: Of 291 MEN1 patients, 242 had HPT (83.2%). Two of the 242 
      patients (0.8%) had a histopathologic diagnosis of PC, and 1 (0.4%) had a 
      diagnosis of APN. The patients with PC were male, ages 62 and 56 years at the 
      time of surgery; the patient with APN was female, age 32 years. All patients also 
      had a pancreatic endocrine tumor. The observed genetic mutations in the PC 
      patients were c.703G > A (p.E235K) in exon 4 and c.1378C > T (p.R460X) in exon 
      10. All 3 patients had recurrence of hypercalcemia, and 2 patients underwent 
      reoperation; pathologic analysis revealed the presence of a hyperplastic gland, 
      not tumor recurrence. No cases had distant metastasis. CONCLUSIONS: This is the 
      first report of APN in an MEN1 patient. Although rare, the presence of PC or APN 
      in MEN1 is noteworthy because it affects the management if hypercalcemia recurs, 
      possibly requiring an open approach rather than the minimally invasive techniques 
      used in the reoperative setting for benign disease.
CI  - Copyright (c) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Christakis, Ioannis
AU  - Christakis I
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA.
FAU - Busaidy, Naifa L
AU  - Busaidy NL
AD  - Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas 
      MD Anderson Cancer Center, Houston, TX, USA.
FAU - Cote, Gilbert J
AU  - Cote GJ
AD  - Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas 
      MD Anderson Cancer Center, Houston, TX, USA.
FAU - Williams, Michelle D
AU  - Williams MD
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX, USA.
FAU - Hyde, Samuel M
AU  - Hyde SM
AD  - Department of Clinical Cancer Genetics, The University of Texas MD Anderson 
      Cancer Center, Houston, TX, USA.
FAU - Silva Figueroa, Angelica M
AU  - Silva Figueroa AM
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA.
FAU - Kwatampora, Lily Joy
AU  - Kwatampora LJ
AD  - Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas 
      MD Anderson Cancer Center, Houston, TX, USA.
FAU - Clarke, Callisia N
AU  - Clarke CN
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA.
FAU - Qiu, Wei
AU  - Qiu W
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA; The First Hospital of Jilin University, Hepatobiliary 
      Pancreatic Surgical Department, Changchun, Jilin, China.
FAU - Lee, Jeffrey E
AU  - Lee JE
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA.
FAU - Perrier, Nancy D
AU  - Perrier ND
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA. Electronic address: nperrier@mdanderson.org.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20160519
PL  - United States
TA  - Int J Surg
JT  - International journal of surgery (London, England)
JID - 101228232
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/genetics/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*pathology
MH  - Mutation
MH  - Parathyroid Glands/pathology/surgery
MH  - Parathyroid Neoplasms/genetics/*pathology/surgery
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Hypercalcemia
OT  - Multiple endocrine neoplasia type 1 (MEN 1)
OT  - Neoplasm
OT  - Parathyroid carcinoma
OT  - Parathyroid gland
OT  - Parathyroidectomy
OT  - Primary hyperparathyroidism
EDAT- 2016/05/24 06:00
MHDA- 2017/03/17 06:00
CRDT- 2016/05/24 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2016/03/22 00:00 [revised]
PHST- 2016/05/15 00:00 [accepted]
PHST- 2016/05/24 06:00 [entrez]
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
AID - S1743-9191(16)30118-2 [pii]
AID - 10.1016/j.ijsu.2016.05.035 [doi]
PST - ppublish
SO  - Int J Surg. 2016 Jul;31:10-6. doi: 10.1016/j.ijsu.2016.05.035. Epub 2016 May 19.