PMID- 27212658
OWN - NLM
STAT- MEDLINE
DCOM- 20170904
LR  - 20171113
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 219
IP  - 4-5
DP  - 2016 Jul
TI  - Exposure and risk assessment of the Czech population to chlorinated pesticides 
      and polychlorinated biphenyls using archived serum samples from the period 1970 
      to 1990.
PG  - 443-53
LID - S1438-4639(16)30034-7 [pii]
LID - 10.1016/j.ijheh.2016.04.011 [doi]
AB  - The serum samples from the years 1970-1990 archived at the temperature of -20 degrees C 
      in the biobank primarily intended for serological survey performed in the CR 
      since 1960 were pooled and analyzed for DDT, its metabolites, HCB, HCHs, and 
      indicator PCB congeners using up-to-date GC/MS/MS methods to retrospectively 
      assess health risks according to current health guidelines. Samples were pooled 
      based on the decade of sampling, age, gender, and three geographical areas; in 
      adults, one pooled samples consisted of ten and in children of twenty individual 
      samples. Altogether 233 pooled samples were analyzed. For all organochlorine 
      pesticides (OCPs), significant downward trends were observed in the period 
      1970-1990 (p<0.001). The levels of HCB exceeded the Biomonitoring Equivalent (BE) 
      value. The hazard quotient (HQ) in Prague and Ostrava during the 1970s and 1980s 
      was about 40 and in the 1990s it had dropped to about five. In Uherske Hradiste, 
      the HQ in 1975 was one order of magnitude higher (about 170), and had decreased 
      to approximately 12 by 1987. For both HCB and the DDT sum, the BE-related 
      carcinogenic risk of actual concentrations in the past exceeded significantly the 
      individually accepted cancer risk level of 10(-4). The levels of the main PCB 
      congeners in the 1970s through 1990s revealed an upward time trend in all 
      analyzed strata. The highest concentrations were found in the serum of residents 
      from the hot-spot area Uherske Hradiste. Critical PCB sum concentration levels 
      (700ng/g lipid for vulnerable population groups and 1800ng/g lipid for other 
      population groups) were substantially exceeded with an increasing time trend. PCB 
      sum had exceeded HBM II values of 7mug/L of serum since 1980 in all age strata. In 
      conclusion, the body burden of the Czech general population relative to 
      persistent organic pollutants (POPs) in the period 1970 through 1990 
      significantly exceeded currently existing health based limit values. The past 
      exposure might adversely affect the health status of the Czech population.
CI  - Copyright (c) 2016 Elsevier GmbH. All rights reserved.
FAU - Cerna, Milena
AU  - Cerna M
AD  - Charles University in Prague, Third Faculty of Medicine, CZ 100 00, Ruska 87, 
      Prague, Czech Republic. Electronic address: milena.cerna@lf3.cuni.cz.
FAU - Krskova, Andrea
AU  - Krskova A
AD  - National Institute of Public Health, CZ 100 42, Srobarova 48, Prague, Czech 
      Republic.
FAU - Smid, Jiri
AU  - Smid J
AD  - National Institute of Public Health, CZ 100 42, Srobarova 48, Prague, Czech 
      Republic.
FAU - Maly, Marek
AU  - Maly M
AD  - National Institute of Public Health, CZ 100 42, Srobarova 48, Prague, Czech 
      Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160507
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Czech Republic
MH  - Environmental Monitoring/statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Middle Aged
MH  - Pesticides/*blood
MH  - Risk Assessment
MH  - Young Adult
OTO - NOTNLM
OT  - Archived serum samples
OT  - Czech Republic
OT  - Organochlorine pesticides
OT  - Polychlorinated biphenyls
OT  - Risk assessment
EDAT- 2016/05/24 06:00
MHDA- 2017/09/05 06:00
CRDT- 2016/05/24 06:00
PHST- 2016/02/04 00:00 [received]
PHST- 2016/04/21 00:00 [revised]
PHST- 2016/04/23 00:00 [accepted]
PHST- 2016/05/24 06:00 [entrez]
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/09/05 06:00 [medline]
AID - S1438-4639(16)30034-7 [pii]
AID - 10.1016/j.ijheh.2016.04.011 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2016 Jul;219(4-5):443-53. doi: 
      10.1016/j.ijheh.2016.04.011. Epub 2016 May 7.