PMID- 27212809
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20181113
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2016
DP  - 2016
TI  - Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A 
      Comparative Study.
PG  - 5474837
LID - 10.1155/2016/5474837 [doi]
LID - 5474837
AB  - OBJECTIVE: This study compared acute and late effect of single-bout endurance 
      training (ET) and high-intensity interval training (HIIT) on the plasma levels of 
      four inflammatory cytokines and C-reactive protein and insulin-like growth factor 
      1. DESIGN: Cohort study with repeated-measures design. METHODS: Seven healthy 
      untrained volunteers completed a single bout of ET and HIIT on a cycle ergometer. 
      ET and HIIT sessions were held in random order and at least 7 days apart. Blood 
      was drawn before the interventions and 30 min and 2 days after the training 
      sessions. Plasma samples were analyzed with ELISA for the interleukins (IL), 
      IL-1beta, IL-6, and IL-10, monocyte chemoattractant protein-1 (MCP-1), insulin 
      growth factor 1 (IGF-1), and C-reactive protein (CRP). Statistical analysis was 
      with Wilcoxon signed-rank tests. RESULTS: ET led to both a significant acute and 
      long-term inflammatory response with a significant decrease at 30 minutes after 
      exercise in the IL-6/IL-10 ratio (-20%; p = 0.047) and a decrease of MCP-1 
      (-17.9%; p = 0.03). CONCLUSION: This study demonstrates that ET affects the 
      inflammatory response more adversely at 30 minutes after exercise compared to 
      HIIT. However, this is compensated by a significant decrease in MCP-1 at two days 
      associated with a reduced risk of atherosclerosis.
FAU - Kaspar, Felix
AU  - Kaspar F
AD  - Department of Biotechnology, Institute for Biochemistry and Biotechnology, 
      Technical University Braunschweig, 38126 Braunschweig, Germany; School of 
      Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
FAU - Jelinek, Herbert F
AU  - Jelinek HF
AD  - School of Community Health, Charles Sturt University, Albury, NSW 2640, 
      Australia; Australian School of Advanced Medicine, Macquarie University, Sydney, 
      NSW 2109, Australia.
FAU - Perkins, Steven
AU  - Perkins S
AD  - School of Community Health, Charles Sturt University, Albury, NSW 2640, 
      Australia.
FAU - Al-Aubaidy, Hayder A
AU  - Al-Aubaidy HA
AD  - School of Medicine, University of Tasmania, Hobart, TAS 7001, Australia.
FAU - deJong, Bev
AU  - deJong B
AD  - School of Community Health, Charles Sturt University, Albury, NSW 2640, 
      Australia.
FAU - Butkowski, Eugene
AU  - Butkowski E
AD  - School of Community Health, Charles Sturt University, Albury, NSW 2640, 
      Australia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160426
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Reaction/immunology/metabolism
MH  - Adult
MH  - C-Reactive Protein/metabolism
MH  - Exercise/*physiology
MH  - Female
MH  - High-Intensity Interval Training
MH  - Humans
MH  - Inflammation/immunology/*metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Young Adult
PMC - PMC4861798
EDAT- 2016/05/24 06:00
MHDA- 2017/01/18 06:00
PMCR- 2016/04/26
CRDT- 2016/05/24 06:00
PHST- 2016/02/24 00:00 [received]
PHST- 2016/04/01 00:00 [revised]
PHST- 2016/04/03 00:00 [accepted]
PHST- 2016/05/24 06:00 [entrez]
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
PHST- 2016/04/26 00:00 [pmc-release]
AID - 10.1155/2016/5474837 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2016;2016:5474837. doi: 10.1155/2016/5474837. Epub 2016 Apr 
      26.