PMID- 27213033
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20190111
IS  - 2041-1480 (Electronic)
VI  - 7
DP  - 2016
TI  - Ontology-based collection, representation and analysis of drug-associated 
      neuropathy adverse events.
PG  - 29
LID - 10.1186/s13326-016-0069-x [doi]
LID - 29
AB  - BACKGROUND: Neuropathy often occurs following drug treatment such as 
      chemotherapy. Severe instances of neuropathy can result in cessation of 
      life-saving chemotherapy treatment. RESULTS: To support data representation and 
      analysis of drug-associated neuropathy adverse events (AEs), we developed the 
      Ontology of Drug Neuropathy Adverse Events (ODNAE). ODNAE extends the Ontology of 
      Adverse Events (OAE). Our combinatorial approach identified 215 US FDA-licensed 
      small molecule drugs that induce signs and symptoms of various types of 
      neuropathy. ODNAE imports related drugs from the Drug Ontology (DrON) with their 
      chemical ingredients defined in ChEBI. ODNAE includes 139 drug mechanisms of 
      action from NDF-RT and 186 biological processes represented in the Gene Ontology 
      (GO). In total ODNAE contains 1579 terms. Our analysis of the ODNAE knowledge 
      base shows neuropathy-inducing drugs classified under specific molecular entity 
      groups, especially carbon, pnictogen, chalcogen, and heterocyclic compounds. The 
      carbon drug group includes 127 organic chemical drugs. Thirty nine receptor 
      agonist and antagonist terms were identified, including 4 pairs (31 drugs) of 
      agonists and antagonists that share targets (e.g., adrenergic receptor, dopamine, 
      serotonin, and sex hormone receptor). Many drugs regulate neurological system 
      processes (e.g., negative regulation of dopamine or serotonin uptake). SPARQL 
      scripts were used to query the ODNAE ontology knowledge base. CONCLUSIONS: ODNAE 
      is an effective platform for building a drug-induced neuropathy knowledge base 
      and for analyzing the underlying mechanisms of drug-induced neuropathy. The 
      ODNAE-based methods used in this study can also be extended to the representation 
      and study of other categories of adverse events.
FAU - Guo, Abra
AU  - Guo A
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA.
FAU - Racz, Rebecca
AU  - Racz R
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA.
FAU - Hur, Junguk
AU  - Hur J
AD  - School of Medicine and Health Sciences, University of North Dakota, Grand Forks, 
      ND 58203 USA.
FAU - Lin, Yu
AU  - Lin Y
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA.
FAU - Xiang, Zuoshuang
AU  - Xiang Z
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA.
FAU - Zhao, Lili
AU  - Zhao L
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA.
FAU - Rinder, Jordan
AU  - Rinder J
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA.
FAU - Jiang, Guoqian
AU  - Jiang G
AD  - Mayo Clinic, Rochester, MN USA.
FAU - Zhu, Qian
AU  - Zhu Q
AD  - University of Maryland, Baltimore County, Baltimore, MD 21250 USA.
FAU - He, Yongqun
AU  - He Y
AD  - University of Michigan Medical School, Ann Arbor, MI 48109 USA ; Unit for 
      Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for 
      Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, 
      University of Michigan Medical School, 1301 MSRB III, 1150 W. Medical Dr., Ann 
      Arbor, MI 48109 USA.
LA  - eng
GR  - R01 AI081062/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20160521
PL  - England
TA  - J Biomed Semantics
JT  - Journal of biomedical semantics
JID - 101531992
SB  - IM
MH  - *Biological Ontologies
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Nervous System Diseases/*chemically induced
PMC - PMC4875649
EDAT- 2016/05/24 06:00
MHDA- 2017/11/08 06:00
PMCR- 2016/05/21
CRDT- 2016/05/24 06:00
PHST- 2016/04/05 00:00 [received]
PHST- 2016/04/28 00:00 [accepted]
PHST- 2016/05/24 06:00 [entrez]
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2016/05/21 00:00 [pmc-release]
AID - 69 [pii]
AID - 10.1186/s13326-016-0069-x [doi]
PST - epublish
SO  - J Biomed Semantics. 2016 May 21;7:29. doi: 10.1186/s13326-016-0069-x. eCollection 
      2016.