PMID- 27213358
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20220408
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 5
DP  - 2016 May 20
TI  - The Natural Course of Non-Alcoholic Fatty Liver Disease.
LID - 10.3390/ijms17050774 [doi]
LID - 774
AB  - Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic 
      liver disease in the world, paralleling the epidemic of obesity and Type 2 
      diabetes mellitus (T2DM). NAFLD exhibits a histological spectrum, ranging from 
      "bland steatosis" to the more aggressive necro-inflammatory form, non-alcoholic 
      steatohepatitis (NASH) which may accumulate fibrosis to result in cirrhosis. 
      Emerging data suggests fibrosis, rather than NASH per se, to be the most 
      important histological predictor of liver and non-liver related death. 
      Nevertheless, only a small proportion of individuals develop cirrhosis, however 
      the large proportion of the population affected by NAFLD has led to predictions 
      that NAFLD will become a leading cause of end stage liver disease, hepatocellular 
      carcinoma (HCC), and indication for liver transplantation. HCC may arise in 
      non-cirrhotic liver in the setting of NAFLD and is associated with the presence 
      of the metabolic syndrome (MetS) and male gender. The MetS and its components 
      also play a key role in the histological progression of NAFLD, however other 
      genetic and environmental factors may also influence the natural history. The 
      importance of NAFLD in terms of overall survival extends beyond the liver where 
      cardiovascular disease and malignancy represents additional important causes of 
      death.
FAU - Calzadilla Bertot, Luis
AU  - Calzadilla Bertot L
AD  - School of Medicine and Pharmacology, the University of Western Australia, 
      Nedlands, WA 6009, Australia. lcbertot@gmail.com.
FAU - Adams, Leon Anton
AU  - Adams LA
AD  - School of Medicine and Pharmacology, the University of Western Australia, 
      Nedlands, WA 6009, Australia. leon.adams@uwa.edu.au.
AD  - Department of Hepatology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, 
      Australia. leon.adams@uwa.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160520
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - *Carcinoma, Hepatocellular/metabolism/mortality/pathology
MH  - Female
MH  - Humans
MH  - *Liver/metabolism/pathology
MH  - *Liver Cirrhosis/etiology/metabolism/mortality/pathology
MH  - *Liver Neoplasms/metabolism/pathology
MH  - Male
MH  - *Non-alcoholic Fatty Liver Disease/complications/metabolism/mortality/pathology
PMC - PMC4881593
OTO - NOTNLM
OT  - cirrhosis
OT  - fibrosis
OT  - hepatocellular carcinoma
OT  - non-alcoholic steatohepatitis
OT  - non-cirrhotic
OT  - nonalcoholic fatty liver
EDAT- 2016/05/24 06:00
MHDA- 2017/03/07 06:00
PMCR- 2016/05/01
CRDT- 2016/05/24 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2016/05/12 00:00 [revised]
PHST- 2016/05/12 00:00 [accepted]
PHST- 2016/05/24 06:00 [entrez]
PHST- 2016/05/24 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - ijms17050774 [pii]
AID - ijms-17-00774 [pii]
AID - 10.3390/ijms17050774 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 May 20;17(5):774. doi: 10.3390/ijms17050774.