PMID- 27215022
OWN - NLM
STAT- MEDLINE
DCOM- 20160610
LR  - 20181202
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 31
IP  - 6
DP  - 2015 Nov
TI  - Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 
      diabetic neuropathic pain rats.
PG  - 541-8
AB  - Along with the development of economy and society, type 2 diabetic mellitus 
      (T2DM) has become one of the most common diseases at the global level. As one of 
      the complications of T2DM, diabetic neuropathic pain (DNP) stubbornly and 
      chronically affects the health and life of human beings. In the pain field, 
      dorsal root ganglion (DRG) is generally considered as the first stage of the 
      sensory pathway where the hyperexcitability of injured neurons is associated with 
      different kinds of peripheral neuropathic pains. The abnormal electrophysiology 
      is mainly due to the changed properties of voltage-gated sodium channels (VGSCs) 
      and the increased sodium currents (I(Na)). Curcumin is an active ingredient 
      extracted from turmeric and has been demonstrated to ameliorate T2DM and its 
      various complications including DNP effectively. The present study demonstrates 
      that the I(Na) of small-sized DRG neurons are significantly increased with the 
      abnormal electrophysiological characteristics of VGSCs in type 2 diabetic 
      neuropathic pain rats. And these abnormalities can be ameliorated efficaciously 
      by a period of treatment with curcumin.
FAU - Meng, Bo
AU  - Meng B
FAU - Shen, Lu-lu
AU  - Shen LL
FAU - Shi, Xiao-ting
AU  - Shi XT
FAU - Gong, Yong-sheng
AU  - Gong YS
FAU - Fan, Xiao-fang
AU  - Fan XF
FAU - Li, Jun
AU  - Li J
FAU - Cao, Hong
AU  - Cao H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Voltage-Gated Sodium Channels)
RN  - 9NEZ333N27 (Sodium)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Curcumin/*pharmacology
MH  - Diabetes Mellitus, Experimental/complications
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Neuropathies/*drug therapy
MH  - Ganglia, Spinal/cytology/*drug effects/metabolism
MH  - Neuralgia/*drug therapy
MH  - Neurons/drug effects/metabolism
MH  - Rats
MH  - Sodium
MH  - Voltage-Gated Sodium Channels/*physiology
EDAT- 2016/05/25 06:00
MHDA- 2016/06/11 06:00
CRDT- 2016/05/25 06:00
PHST- 2016/05/25 06:00 [entrez]
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2016/06/11 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov;31(6):541-8.