PMID- 27215220
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20181113
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 36
IP  - 7
DP  - 2016 Jul
TI  - Role of the Egami score to predict immunoglobulin resistance in Kawasaki disease 
      among a Western Mediterranean population.
PG  - 905-10
LID - 10.1007/s00296-016-3499-y [doi]
AB  - Kawasaki disease is an acute self-limited systemic vasculitis common in 
      childhood. Intravenous immunoglobulin (IVIG) is an effective treatment, and it 
      reduces the incidence of cardiac complications. Egami score has been validated to 
      identify IVIG non-responder patients in Japanese population, and it has shown 
      high sensitivity and specificity to identify these non-responder patients. 
      Although its effectiveness in Japan, Egami score has shown to be ineffective in 
      non-Japanese populations. The aim of this study was to apply the Egami score in a 
      Western Mediterranean population in Catalonia (Spain). Observational 
      population-based study that includes patients from all Pediatric Units in 33 
      Catalan hospitals, both public and private management, between January 2004 and 
      March 2014. Sensitivity and specificity for the Egami score was calculated, and a 
      logistic regression analysis of predictors of overall response to IVIG was also 
      developed. Predicting IVIG resistance with a cutoff for Egami score >/=3 obtained 
      26 % sensitivity and 82 % specificity. Negative predictive value was 85 % and 
      positive predictive value 22 %. This low sensitivity implies that three out of 
      four non-responders will not be identified by the Egami score. Besides, logistic 
      regression models did not found significance for the use of the Egami score to 
      predict IVIG resistance in Catalan population although having an area under the 
      ROC curve of 0.618 (IC 95 % 0.538-0.698, p < 0.001). Although regression models 
      found an area under the ROC curve >0.5 to predict IVIG resistance, the low 
      sensitivity excludes the Egami score as a useful tool to predict IVIG resistance 
      in Catalan population.
FAU - Sanchez-Manubens, Judith
AU  - Sanchez-Manubens J
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Parc Tauli, 
      C/Parc Tauli, 2, 08208, Sabadell, Barcelona, Spain. jsanchez@tauli.cat.
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain. jsanchez@tauli.cat.
FAU - Anton, Jordi
AU  - Anton J
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain.
FAU - Bou, Rosa
AU  - Bou R
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain.
FAU - Iglesias, Estibaliz
AU  - Iglesias E
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain.
FAU - Calzada-Hernandez, Joan
AU  - Calzada-Hernandez J
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain.
FAU - Borlan, Sergi
AU  - Borlan S
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain.
FAU - Gimenez-Roca, Clara
AU  - Gimenez-Roca C
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Sant Joan de 
      Deu, Esplugues de Llobregat, Barcelona, Spain.
FAU - Rivera, Josefa
AU  - Rivera J
AD  - Unitat de Reumatologia Pediatrica, Servei de Pediatria, Hospital Parc Tauli, 
      C/Parc Tauli, 2, 08208, Sabadell, Barcelona, Spain.
CN  - Kawasaki Disease in Catalonia Working Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20160523
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adolescent
MH  - Area Under Curve
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - *Decision Support Techniques
MH  - *Drug Resistance
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Immunologic Factors/*administration & dosage
MH  - Logistic Models
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/diagnosis/*drug therapy/epidemiology/immunology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Spain/epidemiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Coronary aneurism
OT  - Egami score
OT  - Immunoglobulin resistance
OT  - Kawasaki disease
FIR - Garcia, Lourdes
IR  - Garcia L
FIR - Caubet, Imma
IR  - Caubet I
FIR - Fabrega, Jordi
IR  - Fabrega J
FIR - Fernandez, Anna
IR  - Fernandez A
FIR - Alegre, Adolfo
IR  - Alegre A
FIR - Zambudio, Isabel
IR  - Zambudio I
FIR - Delgado, Lluis
IR  - Delgado L
FIR - Garcia, Pablo
IR  - Garcia P
FIR - Serrano, Angelita
IR  - Serrano A
FIR - Sala, Pere
IR  - Sala P
FIR - Villalobos, Pilar
IR  - Villalobos P
FIR - Conradi, AlvaroDiaz
IR  - Conradi A
FIR - Agullo, Joan
IR  - Agullo J
FIR - Uriz, Socorro
IR  - Uriz S
FIR - Sanchez, Aina
IR  - Sanchez A
FIR - Bonet, Mariona
IR  - Bonet M
FIR - Gispert-Sauch, Montserrat
IR  - Gispert-Sauch M
FIR - Corral, Sonia
IR  - Corral S
FIR - Lobato, Zulema
IR  - Lobato Z
FIR - Domenech, Pere
IR  - Domenech P
FIR - Mendez, Maria
IR  - Mendez M
FIR - Calavia, Olga
IR  - Calavia O
FIR - Tobena, Marc
IR  - Tobena M
FIR - Munoz, EmilianoMora
IR  - Munoz E
FIR - Sans, Gemma
IR  - Sans G
FIR - Carrera, Montse
IR  - Carrera M
FIR - Monaco, Ernesto
IR  - Monaco E
FIR - Ballester, Anna
IR  - Ballester A
FIR - Foguet, Anton
IR  - Foguet A
FIR - Escribano, Joaquin
IR  - Escribano J
FIR - Rius, Neus
IR  - Rius N
FIR - Moral, Angel
IR  - Moral A
FIR - Alvarez, Roser
IR  - Alvarez R
FIR - Sorni, Toni
IR  - Sorni T
FIR - Molina, Vicente
IR  - Molina V
FIR - Sanz, Mario
IR  - Sanz M
FIR - Terradas, Pilar
IR  - Terradas P
FIR - Salcedo, Salvador
IR  - Salcedo S
FIR - Martinez, Olga
IR  - Martinez O
EDAT- 2016/05/25 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/05/25 06:00
PHST- 2016/02/06 00:00 [received]
PHST- 2016/05/12 00:00 [accepted]
PHST- 2016/05/25 06:00 [entrez]
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
AID - 10.1007/s00296-016-3499-y [pii]
AID - 10.1007/s00296-016-3499-y [doi]
PST - ppublish
SO  - Rheumatol Int. 2016 Jul;36(7):905-10. doi: 10.1007/s00296-016-3499-y. Epub 2016 
      May 23.