PMID- 27216537
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20181113
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Print)
IS  - 0301-4851 (Linking)
VI  - 43
IP  - 7
DP  - 2016 Jul
TI  - Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and 
      DNA methyltransferase (DNMT) activity in the mouse brain.
PG  - 711-7
LID - 10.1007/s11033-016-4006-y [doi]
AB  - The aim of our study was to investigate the brain-specific epigenetic effects on 
      global enzymatic histone deacetylase (HDAC) and DNA methyltransferase (DNMT) 
      activity after prenatal exposure to maternal immune challenge by 
      polyinosinic:polycytidylic acid (Poly I:C) at gestational day (GD) 17 in 
      C57BL/6JRccHsd mouse offspring. Pregnant mice were randomly divided into 2 
      groups, receiving either 5 mg/kg Poly I:C or phosphate buffered saline (PBS) 
      intravenously at GD 17. Subsequently, the effects on whole brain enzymatic HDAC 
      and DNMT activity and the protein levels of various HDAC isoforms were assessed 
      in the offspring. Overall, a significant sex x treatment interaction effect was 
      observed after prenatal exposure to maternal immune challenge by Poly I:C, 
      indicative of increased global HDAC activity particularly in female offspring 
      from mothers injected with Poly I:C when compared to controls. Results on the 
      levels of specific HDAC isoforms suggested that neither differences in the levels 
      of HDAC1, HDAC2, HDAC3, HDAC4 or HDAC6 could explain the increased global HDAC 
      activity observed in female Poly I:C offspring. In conclusion, we show that Poly 
      I:C administration to pregnant mice alters global brain HDAC, but not DNMT 
      activity in adult offspring, whereas it is still unclear which specific HDAC(s) 
      mediate(s) this effect. These results indicate the necessity for further research 
      on the epigenetic effects of Poly I:C.
FAU - Pujol Lopez, Yara
AU  - Pujol Lopez Y
AD  - School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and 
      Neuropsychology, Maastricht University Medical Centre+, Universiteitssingel 50, 
      Room 1.148, 6229 ER, Maastricht, The Netherlands. yarapujol@gmail.com.
FAU - Kenis, Gunter
AU  - Kenis G
AD  - School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and 
      Neuropsychology, Maastricht University Medical Centre+, Universiteitssingel 50, 
      Room 1.148, 6229 ER, Maastricht, The Netherlands.
FAU - Stettinger, Waldtraud
AU  - Stettinger W
AD  - Psychiatric Hospital, Ludwig-Maximilian University, Munich, Germany.
FAU - Neumeier, Karin
AU  - Neumeier K
AD  - Psychiatric Hospital, Ludwig-Maximilian University, Munich, Germany.
FAU - de Jonge, Sylvia
AU  - de Jonge S
AD  - Psychiatric Hospital, Ludwig-Maximilian University, Munich, Germany.
FAU - Steinbusch, Harry W M
AU  - Steinbusch HW
AD  - School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and 
      Neuropsychology, Maastricht University Medical Centre+, Universiteitssingel 50, 
      Room 1.148, 6229 ER, Maastricht, The Netherlands.
FAU - Zill, Peter
AU  - Zill P
AD  - Psychiatric Hospital, Ludwig-Maximilian University, Munich, Germany.
FAU - van den Hove, Daniel L A
AU  - van den Hove DL
AD  - School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and 
      Neuropsychology, Maastricht University Medical Centre+, Universiteitssingel 50, 
      Room 1.148, 6229 ER, Maastricht, The Netherlands.
AD  - Laboratory of Translational Neuroscience, Department of Psychiatry, 
      Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany.
FAU - Myint, Aye M
AU  - Myint AM
AD  - School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and 
      Neuropsychology, Maastricht University Medical Centre+, Universiteitssingel 50, 
      Room 1.148, 6229 ER, Maastricht, The Netherlands.
AD  - Psychiatric Hospital, Ludwig-Maximilian University, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160523
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
RN  - EC 3.5.1.98 (Histone Deacetylases)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*enzymology/immunology
MH  - DNA (Cytosine-5-)-Methyltransferases/genetics/*metabolism
MH  - Epigenesis, Genetic/drug effects
MH  - Female
MH  - Histone Deacetylases/genetics/*metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Poly I-C/*pharmacology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/enzymology/*immunology
PMC - PMC4906067
OTO - NOTNLM
OT  - Epigenetics
OT  - HDAC
OT  - Infection
OT  - Mouse
OT  - Poly I:C
OT  - Pregnancy
EDAT- 2016/05/25 06:00
MHDA- 2017/02/18 06:00
PMCR- 2016/05/23
CRDT- 2016/05/25 06:00
PHST- 2015/09/30 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/05/25 06:00 [entrez]
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
PHST- 2016/05/23 00:00 [pmc-release]
AID - 10.1007/s11033-016-4006-y [pii]
AID - 4006 [pii]
AID - 10.1007/s11033-016-4006-y [doi]
PST - ppublish
SO  - Mol Biol Rep. 2016 Jul;43(7):711-7. doi: 10.1007/s11033-016-4006-y. Epub 2016 May 
      23.