PMID- 27216762
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20190320
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 254
IP  - 11
DP  - 2016 Nov
TI  - Outer retinal deformity detected by optical coherence tomography in eyes with 
      foveal hypoplasia.
PG  - 2197-2201
AB  - PURPOSE: To investigate the relationship between vision and foveal maturity, 
      especially in foveal hypoplasia exhibiting severe structural immaturity. METHODS: 
      This retrospective observational case series included 42 eyes of 23 patients 
      (mean age, 7.0 +/- 5.0 years; 9 patients with foveal hypoplasia as an isolated 
      entity and 14 patients with aniridia). A complete ophthalmic examination included 
      measurement of best-corrected visual acuity (BCVA) and spectral-domain optical 
      coherence tomography (SD-OCT). The sensory retina, ganglion cell complex (GCC), 
      and outer retinal layers, including Henle's fiber layer (HFL), were measured and 
      analyzed. RESULTS: Using SD-OCT images, eyes were classified as having a 
      differentiated (6 eyes), diffuse (19 eyes), or no HFL (17 eyes), based on the 
      appearance of the HFL around the foveal region. The logMAR BCVA was significantly 
      worse (p < 0.0001) in eyes with diffuse HFL and those with no HFL than in those 
      with differentiated HFL. Outer retinal thickness (outer plexiform layer + HFL + 
      outer nuclear layer) was less (p = 0.0051) in eyes with no HFL than in those with 
      differentiated HFL. The logMAR BCVA, GCC thickness, and outer retinal thickness 
      in eyes with foveal hypoplasia with aniridia were significantly worse 
      (p = 0.0083), thicker (p = 0.0039), and thinner (p = 0.0001), respectively, than 
      in eyes with foveal hypoplasia as an isolated entity. CONCLUSIONS: In eyes with 
      foveal hypoplasia with severe structural immaturity, diffuse HFL or no HFL was 
      associated with worse vision. There was greater foveal immaturity in eyes with 
      foveal hypoplasia with aniridia compared with foveal hypoplasia as an isolated 
      entity.
FAU - Katagiri, Satoshi
AU  - Katagiri S
AD  - Department of Ophthalmology and Laboratory for Visual Science, National Center 
      for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, 
      Japan.
AD  - Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, 
      Japan.
FAU - Yokoi, Tadashi
AU  - Yokoi T
AD  - Department of Ophthalmology and Laboratory for Visual Science, National Center 
      for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, 
      Japan.
FAU - Mikami, Masashi
AU  - Mikami M
AD  - Division of Biostatistics, Center for Clinical Research and Development, National 
      Center for Child Health and Development, Tokyo, Japan.
FAU - Nishina, Sachiko
AU  - Nishina S
AD  - Department of Ophthalmology and Laboratory for Visual Science, National Center 
      for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, 
      Japan.
FAU - Azuma, Noriyuki
AU  - Azuma N
AD  - Department of Ophthalmology and Laboratory for Visual Science, National Center 
      for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, 
      Japan. azuma-n@ncchd.go.jp.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160523
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Eye Abnormalities/*diagnosis
MH  - Female
MH  - Fovea Centralis/*abnormalities
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
OTO - NOTNLM
OT  - Aniridia
OT  - Foveal hypoplasia
OT  - Henle's fiber layer
OT  - Isolated
OT  - Optical coherence tomography
EDAT- 2016/10/27 06:00
MHDA- 2019/03/21 06:00
CRDT- 2016/05/25 06:00
PHST- 2016/01/19 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/05/07 00:00 [revised]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2016/05/25 06:00 [entrez]
AID - 10.1007/s00417-016-3385-z [pii]
AID - 10.1007/s00417-016-3385-z [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2016 Nov;254(11):2197-2201. doi: 
      10.1007/s00417-016-3385-z. Epub 2016 May 23.