PMID- 27216894
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20171128
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 138
IP  - 3
DP  - 2016 Aug
TI  - Estradiol-induced neurogenesis in the female accessory olfactory bulb is required 
      for the learning of the male odor.
PG  - 457-68
LID - 10.1111/jnc.13677 [doi]
AB  - Odors processed by the main and accessory olfactory bulbs (MOB, AOB) are 
      important for sexual behavior. Interestingly, both structures continue to receive 
      new neurons during adulthood. A role for olfactory neurogenesis in sexual 
      behavior in female mice has recently been shown and gonadal hormones such as 
      estradiol can modulate adult neurogenesis. Therefore, we wanted to determine the 
      role of estradiol in learning the odors of sexual partners and in the adult 
      neurogenesis of female aromatase knockout mice (ArKO), unable to produce 
      estradiol. Female wild-type (WT) and ArKO mice were exposed to male odors during 
      7 days, and olfactory preferences, cell proliferation, cell survival and 
      functional involvement of newborn neurons were analyzed, using BrdU injections, 
      in combination with a marker of cell activation (Zif268) and neuronal fate 
      (doublecortin, NeuN). Behavioral tasks indicated that both WT and ArKO females 
      were able to discriminate between the odors of two different males, but ArKO mice 
      failed to learn the familiar male odor. Proliferation of newborn cells was 
      reduced in ArKO mice only in the dentate gyrus of the hippocampus. Olfactory 
      exposure decreased cell survival in the AOB in WT females, suggesting a role for 
      estradiol in a structure involved in sexual behavior. Finally, newborn neurons do 
      not seem to be functionally involved in the AOB of ArKO mice compared with WT, 
      when females were exposed to the odor of a familiar male, suggesting that 
      estradiol-induced neurogenesis in the AOB is required for the learning of the 
      male odor in female mice. Aromatase knockout mice (ArKO) presented deficits in 
      olfactory preferences without affecting their olfactory discrimination abilities, 
      and showed no functional involvement of newborn neurons in the accessory 
      olfactory bulb (AOB) in response to the odor of a familiar male. These results 
      suggest that estradiol-induced neurogenesis in the female AOB is required for the 
      learning of the male odor.
CI  - (c) 2016 International Society for Neurochemistry.
FAU - Brus, Maina
AU  - Brus M
AD  - Laboratory of Neuroendocrinology, Groupe Interdisciplinaire de Genoproteomique 
      Appliquee (GIGA) Neurosciences, University of Liege, Liege, Belgium.
FAU - Trouillet, Anne-Charlotte
AU  - Trouillet AC
AD  - Laboratory of Neuroendocrinology, Groupe Interdisciplinaire de Genoproteomique 
      Appliquee (GIGA) Neurosciences, University of Liege, Liege, Belgium.
FAU - Hellier, Vincent
AU  - Hellier V
AD  - Laboratory of Neuroendocrinology, Groupe Interdisciplinaire de Genoproteomique 
      Appliquee (GIGA) Neurosciences, University of Liege, Liege, Belgium.
FAU - Bakker, Julie
AU  - Bakker J
AD  - Laboratory of Neuroendocrinology, Groupe Interdisciplinaire de Genoproteomique 
      Appliquee (GIGA) Neurosciences, University of Liege, Liege, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160714
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Learning/*drug effects
MH  - Male
MH  - Mice, Knockout
MH  - Neurogenesis/*drug effects/physiology
MH  - Neurons/*drug effects
MH  - Odorants
MH  - Olfactory Bulb/cytology/*drug effects
MH  - Ovariectomy/methods
MH  - Sex Characteristics
MH  - Smell/physiology
OTO - NOTNLM
OT  - aromatase knockout mice
OT  - cell proliferation
OT  - cell survival
OT  - functional integration
OT  - olfactory stimulation
EDAT- 2016/05/25 06:00
MHDA- 2017/06/15 06:00
CRDT- 2016/05/25 06:00
PHST- 2015/09/17 00:00 [received]
PHST- 2016/04/20 00:00 [revised]
PHST- 2016/05/12 00:00 [accepted]
PHST- 2016/05/25 06:00 [entrez]
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
AID - 10.1111/jnc.13677 [doi]
PST - ppublish
SO  - J Neurochem. 2016 Aug;138(3):457-68. doi: 10.1111/jnc.13677. Epub 2016 Jul 14.