PMID- 27216915
OWN - NLM
STAT- MEDLINE
DCOM- 20170605
LR  - 20240326
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Print)
IS  - 1742-5247 (Linking)
VI  - 13
IP  - 11
DP  - 2016 Nov
TI  - Albumin nanostructures as advanced drug delivery systems.
PG  - 1609-1623
AB  - One of the biggest impacts that the nanotechnology has made on medicine and 
      biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer 
      from serious problems concerning insolubility, instability in biological 
      environments, poor uptake into cells and tissues, sub-optimal selectivity for 
      targets and unwanted side effects. Nanocarriers can be designed as DDSs to 
      overcome many of these drawbacks. One of the most versatile building blocks to 
      prepare these nanocarriers is the ubiquitous, readily available and inexpensive 
      protein, serum albumin. Areas covered: This review covers the use of different 
      types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle 
      and microparticle-based structures to bind drugs. Various methods have been used 
      to modify the albumin structure. A range of targeting ligands can be attached to 
      the albumin that can be recognized by specific cell receptors that are expressed 
      on target cells or tissues. Expert opinion: The particular advantages of albumin 
      used in DDSs include ready availability, ease of chemical modification, good 
      biocompatibility, and low immunogenicity. The regulatory approvals that have been 
      received for several albumin-based therapeutic agents suggest that this approach 
      will continue to be successfully explored.
FAU - Karimi, Mahdi
AU  - Karimi M
AD  - a Department of Medical Nanotechnology, Faculty of Advanced Technologies in 
      Medicine , Iran University of Medical Sciences , Tehran , Iran.
FAU - Bahrami, Sajad
AU  - Bahrami S
AD  - a Department of Medical Nanotechnology, Faculty of Advanced Technologies in 
      Medicine , Iran University of Medical Sciences , Tehran , Iran.
AD  - b Nanomedicine Research Association (NRA) , Universal Scientific Education and 
      Research Network (USERN) , Tehran , Iran.
FAU - Ravari, Soodeh Baghaee
AU  - Ravari SB
AD  - c Joint School of Nanoscience and Nanoengineering , University of North Carolina 
      at Greensboro , Greensboro , NC , USA.
FAU - Zangabad, Parham Sahandi
AU  - Zangabad PS
AD  - d Department of Materials Science and Engineering , Sharif University of 
      Technology , Tehran , Iran.
FAU - Mirshekari, Hamed
AU  - Mirshekari H
AD  - e Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG) , Iran 
      University of Medical Sciences , Tehran , Iran.
FAU - Bozorgomid, Mahnaz
AU  - Bozorgomid M
AD  - f Department of Applied Chemistry , Islamic Azad University, Central Tehran 
      Branch , Tehran , Iran.
FAU - Shahreza, Somayeh
AU  - Shahreza S
AD  - g Department of Microbiology, School of Biology , University College of Sciences, 
      University of Tehran , Tehran , Iran.
FAU - Sori, Masume
AU  - Sori M
AD  - a Department of Medical Nanotechnology, Faculty of Advanced Technologies in 
      Medicine , Iran University of Medical Sciences , Tehran , Iran.
FAU - Hamblin, Michael R
AU  - Hamblin MR
AD  - h Wellman Center for Photomedicine , Massachusetts General Hospital , Boston , MA 
      , USA.
AD  - i Department of Dermatology , Harvard Medical School , Boston , MA , USA.
AD  - j Harvard-MIT Division of Health Sciences and Technology , Cambridge , MA , USA.
LA  - eng
GR  - R01 AI050875/AI/NIAID NIH HHS/United States
GR  - R21 AI121700/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20160603
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Albumins)
RN  - 0 (Drug Carriers)
RN  - 0 (Ligands)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Albumins/*chemistry
MH  - Animals
MH  - Cattle
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Ligands
MH  - Nanoparticles
MH  - *Nanostructures
MH  - Nanotechnology
MH  - Pharmaceutical Preparations/administration & dosage
MH  - Rats
PMC - PMC5063715
MID - NIHMS820474
OTO - NOTNLM
OT  - Human serum albumin
OT  - bovine serum albumin
OT  - drug delivery systems
OT  - nanoparticles
OT  - ovalbumin
EDAT- 2016/05/25 06:00
MHDA- 2017/06/06 06:00
PMCR- 2017/11/01
CRDT- 2016/05/25 06:00
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2017/06/06 06:00 [medline]
PHST- 2016/05/25 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 10.1080/17425247.2016.1193149 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2016 Nov;13(11):1609-1623. doi: 
      10.1080/17425247.2016.1193149. Epub 2016 Jun 3.