PMID- 2721822
OWN - NLM
STAT- MEDLINE
DCOM- 19890627
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 38
IP  - 6
DP  - 1989 Jun
TI  - Effect of carbohydrate intake on kidney function and structure in SHR/N-cp rats. 
      A new model of NIDDM.
PG  - 679-85
AB  - The SHR/N corpulent (cp) rat is a genetically obese rat that develops 
      hyperglycemia, hyperinsulinemia, and proteinuria. This study was designed to 
      evaluate the effects of high carbohydrate (CHO) intake on renal function and 
      structure in this animal model and to determine whether the renal effects are 
      related to the type of CHO ingested. Two groups of 5-wk-old obese male SHR/N-cp 
      rats and lean male littermates were fed diets containing 54% CHO in the form of 
      sucrose or starch. After 12 wk, renal function parameters, including creatinine 
      clearance, urinary glucose excretion, and urinary protein excretion, were 
      measured. Renal morphology was evaluated by semiquantitative light and electron 
      microscopy. On either diet, obese rats had significantly higher urinary glucose 
      and protein excretions than their lean littermates. Mean creatinine clearance 
      (ml/min) in obese rats did not differ significantly from values observed in lean 
      rats. When corrected for body weight, creatinine clearance (ml.min-1.kg-1) tended 
      to be lower in obese than in lean rats, but the difference was significant (P 
      less than .02) only for obese and lean sucrose-fed animals. Obese rats fed 
      sucrose compared with their obese counterparts fed starch had higher body weight 
      (+8%, P less than .05), glucose excretion (+63%, P less than .02), and protein 
      excretion (+242%, P less than .005). In obese rats, protein excretion correlated 
      with glucose excretion (r = .71, P less than .01). Glomerular lesions consisting 
      of mesangial expansion and intercapillary nodules were found in obese but not in 
      lean rats. Moreover, obese rats fed sucrose had a significantly greater number of 
      involved glomeruli than obese rats fed starch.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Velasquez, M T
AU  - Velasquez MT
AD  - Department of Medicine, George Washington University Medical Center, Washington, 
      DC 20037.
FAU - Kimmel, P L
AU  - Kimmel PL
FAU - Michaelis, O E 4th
AU  - Michaelis OE 4th
FAU - Carswell, N
AU  - Carswell N
FAU - Abraham, A
AU  - Abraham A
FAU - Bosch, J P
AU  - Bosch JP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Dietary Carbohydrates)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/pathology/*physiopathology
MH  - Diabetes Mellitus, Type 2/pathology/*physiopathology
MH  - Dietary Carbohydrates/*pharmacology
MH  - Glomerular Mesangium/*pathology/ultrastructure
MH  - Glycosuria
MH  - Kidney/drug effects/physiology/*physiopathology
MH  - Kidney Function Tests
MH  - Kidney Glomerulus/cytology/*pathology
MH  - Male
MH  - Microscopy, Electron
MH  - Proteinuria
MH  - Rats
MH  - Rats, Inbred SHR/*physiology
MH  - Rats, Inbred Strains/*physiology
EDAT- 1989/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.2337/diab.38.6.679 [doi]
PST - ppublish
SO  - Diabetes. 1989 Jun;38(6):679-85. doi: 10.2337/diab.38.6.679.