PMID- 27219013
OWN - NLM
STAT- MEDLINE
DCOM- 20180116
LR  - 20181113
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Print)
IS  - 2059-2302 (Linking)
VI  - 87
IP  - 6
DP  - 2016 Jun
TI  - A comparative reference study for the validation of HLA-matching algorithms in 
      the search for allogeneic hematopoietic stem cell donors and cord blood units.
PG  - 439-48
LID - 10.1111/tan.12817 [doi]
AB  - The accuracy of human leukocyte antigen (HLA)-matching algorithms is a 
      prerequisite for the correct and efficient identification of optimal unrelated 
      donors for patients requiring hematopoietic stem cell transplantation. The goal 
      of this World Marrow Donor Association study was to validate established matching 
      algorithms from different international donor registries by challenging them with 
      simulated input data and subsequently comparing the output. This experiment 
      addressed three specific aspects of HLA matching using different data sets for 
      tasks of increasing complexity. The first two tasks targeted the traditional 
      matching approach identifying discrepancies between patient and donor HLA 
      genotypes by counting antigen and allele differences. Contemporary matching 
      procedures predicting the probability for HLA identity using haplotype 
      frequencies were addressed by the third task. In each task, the identified 
      disparities between the results of the participating computer programs were 
      analyzed, classified and quantified. This study led to a deep understanding of 
      the algorithms participating and finally produced virtually identical results. 
      The unresolved discrepancies total to less than 1%, 4% and 2% for the three tasks 
      and are mostly because of individual decisions in the design of the programs. 
      Based on these findings, reference results for the three input data sets were 
      compiled that can be used to validate future matching algorithms and thus improve 
      the quality of the global donor search process.
CI  - (c) 2016 The Authors. HLA published by John Wiley & Sons Ltd.
FAU - Bochtler, W
AU  - Bochtler W
AD  - Zentrales Knochenmarkspender-Register Deutschland (ZKRD), Ulm, Germany.
FAU - Gragert, L
AU  - Gragert L
AUID- ORCID: 0000-0002-5945-6518
AD  - National Marrow Donor Program (NMDP), Minneapolis, MN, USA.
FAU - Patel, Z I
AU  - Patel ZI
AD  - Anthony Nolan Research Institute (ANRI), Royal Free Hospital, London, UK.
FAU - Robinson, J
AU  - Robinson J
AD  - Anthony Nolan Research Institute (ANRI), Royal Free Hospital, London, UK.
AD  - UCL Cancer Institute, Royal Free Campus, London, UK.
FAU - Steiner, D
AU  - Steiner D
AD  - Czech Stem Cells Registry (CSCR) and Department of Cybernetics, Czech Technical 
      University, Prague, Czech Republic.
FAU - Hofmann, J A
AU  - Hofmann JA
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany.
FAU - Pingel, J
AU  - Pingel J
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany.
FAU - Baouz, A
AU  - Baouz A
AD  - Agence de la biomedecine - Registre France Greffe de Moelle (FGM), Paris, France.
FAU - Melis, A
AU  - Melis A
AD  - Bone Marrow Donors Worldwide (BMDW) and Europdonor operated by Matchis, Leiden, 
      The Netherlands.
FAU - Schneider, J
AU  - Schneider J
AD  - National Marrow Donor Program (NMDP), Minneapolis, MN, USA.
FAU - Eberhard, H-P
AU  - Eberhard HP
AD  - Zentrales Knochenmarkspender-Register Deutschland (ZKRD), Ulm, Germany.
FAU - Oudshoorn, M
AU  - Oudshoorn M
AD  - Bone Marrow Donors Worldwide (BMDW) and Europdonor operated by Matchis, Leiden, 
      The Netherlands.
FAU - Marsh, S G E
AU  - Marsh SG
AD  - Anthony Nolan Research Institute (ANRI), Royal Free Hospital, London, UK.
AD  - UCL Cancer Institute, Royal Free Campus, London, UK.
FAU - Maiers, M
AU  - Maiers M
AD  - National Marrow Donor Program (NMDP), Minneapolis, MN, USA.
FAU - Muller, C R
AU  - Muller CR
AD  - Zentrales Knochenmarkspender-Register Deutschland (ZKRD), Ulm, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160524
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Algorithms
MH  - *Alleles
MH  - *Cord Blood Stem Cell Transplantation
MH  - Datasets as Topic
MH  - Gene Frequency
MH  - HLA Antigens/classification/*genetics/immunology
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Registries
MH  - Transplant Recipients
MH  - Transplantation, Homologous
MH  - Unrelated Donors
PMC - PMC5089599
OTO - NOTNLM
OT  - donor registry
OT  - hematopoietic stem cell transplantation
OT  - human leukocyte antigen
OT  - immunogenetics
OT  - matching algorithm
OT  - patient-donor matching
EDAT- 2016/05/25 06:00
MHDA- 2018/01/18 06:00
PMCR- 2016/11/01
CRDT- 2016/05/25 06:00
PHST- 2015/11/27 00:00 [received]
PHST- 2016/04/19 00:00 [revised]
PHST- 2016/04/22 00:00 [accepted]
PHST- 2016/05/25 06:00 [entrez]
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - TAN12817 [pii]
AID - 10.1111/tan.12817 [doi]
PST - ppublish
SO  - HLA. 2016 Jun;87(6):439-48. doi: 10.1111/tan.12817. Epub 2016 May 24.