PMID- 27219111
OWN - NLM
STAT- MEDLINE
DCOM- 20170927
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 125
IP  - 1
DP  - 2017 Jan
TI  - Persistent Organic Pollutants and the Association with Maternal and Infant 
      Thyroid Homeostasis: A Multipollutant Assessment.
PG  - 127-133
LID - 10.1289/EHP152 [doi]
AB  - BACKGROUND: Disruption of thyroid homeostasis has been indicated in human studies 
      targeting effects of persistent organic pollutants (POPs). Influence on the 
      maternal thyroid system by POPs is of special interest during pregnancy because 
      such effects could impair infant thyroid homeostasis. OBJECTIVES: We investigated 
      the association between POPs and thyroid-stimulating hormone (TSH) and thyroid 
      hormones (THs) in mother and child pairs from the Northern Norway 
      Mother-and-Child Contaminant Cohort Study (MISA). METHODS: Nineteen POPs and 10 
      thyroid parameters were analyzed in serum from 391 pregnant women in their second 
      trimester. In addition, TSH concentrations in heel-prick samples from the infants 
      were analyzed by the Norwegian Newborn Screening program. Association studies 
      with a multipollutant approach were performed using multivariate analyses; 
      partial least squares (PLS) regression, hierarchical clustering, and principal 
      component analysis (PCA). RESULTS: Several POPs were significantly associated 
      with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and 
      nonachlors were inversely associated with T3, T4, and FT4; and, c) PFDA and 
      PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for 
      the other contaminants, only PFDA and PFUnDA remained significantly associated 
      with T3 and FT3, respectively. Infants born to mothers within the highest TSH 
      quartile had 10% higher mean concentrations of TSH compared with children born to 
      mothers in the lowest TSH quartile. CONCLUSION: The present results suggest that 
      background exposures to POPs can alter maternal thyroid homeostasis. This 
      research contributes to the understanding of multipollutant exposures using 
      multivariate statistical approaches and highlights the complexity of 
      investigating environmental concentrations and mixtures in regard to maternal and 
      infant thyroid function. Citation: Berg V, Nost TH, Pettersen RD, Hansen S, Veyhe 
      AS, Jorde R, Odland JO, Sandanger TM. 2017. Persistent organic pollutants and the 
      association with maternal and infant thyroid homeostasis: a multipollutant 
      assessment. Environ Health Perspect 
      125:127-133; http://dx.doi.org/10.1289/EHP152.
FAU - Berg, Vivian
AU  - Berg V
AD  - Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway.
FAU - Nost, Therese Haugdahl
AU  - Nost TH
FAU - Pettersen, Rolf Dagfinn
AU  - Pettersen RD
FAU - Hansen, Solrunn
AU  - Hansen S
FAU - Veyhe, Anna-Sofia
AU  - Veyhe AS
FAU - Jorde, Rolf
AU  - Jorde R
FAU - Odland, Jon Oyvind
AU  - Odland JO
FAU - Sandanger, Torkjel Manning
AU  - Sandanger TM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160524
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Thyroid Hormones)
RN  - 9002-71-5 (Thyrotropin)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cohort Studies
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Homeostasis/physiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Maternal Exposure/*statistics & numerical data
MH  - Norway
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - Thyroid Gland
MH  - Thyroid Hormones/blood
MH  - Thyrotropin/blood
MH  - Young Adult
PMC - PMC5226691
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2016/05/25 06:00
MHDA- 2017/09/28 06:00
PMCR- 2017/01/01
CRDT- 2016/05/25 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2016/02/11 00:00 [revised]
PHST- 2016/05/09 00:00 [accepted]
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/05/25 06:00 [entrez]
PHST- 2017/01/01 00:00 [pmc-release]
AID - EHP152 [pii]
AID - 10.1289/EHP152 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2017 Jan;125(1):127-133. doi: 10.1289/EHP152. Epub 2016 
      May 24.