PMID- 27219884
OWN - NLM
STAT- MEDLINE
DCOM- 20170303
LR  - 20220311
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 124
IP  - 8
DP  - 2016 Sep
TI  - Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation 
      After Angioplasty for Diabetic Foot.
PG  - 497-503
AB  - Aims: The multilineage differentiation potential of human umbilical cord 
      mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers 
      and tissue regeneration. The present study evaluated the effects of HUCMSC 
      transplantation after angioplasty for treatment of diabetic foot. Methods: 
      Included in the study were 53 patients (72 limbs) with severe symptoms of 
      Fontaine II-IV diabetic foot accompanied by varying degrees of lower extremity 
      arterial disease. The patients were randomly apportioned to a control group (25 
      patients; 38 limbs) or an experimental group (28 patients; 34 limbs). Patients of 
      both groups received interventional treatment with angioplasty; those in the 
      experimental group also received HUCMSCs by endovascular infusion and injection 
      around the foot ulcer. Results: Within the 3-month follow-up, relative to 
      patients in the control group, those in the experimental group experienced 
      significantly greater and more stable improvements in skin temperature, 
      ankle-brachial pressure index, transcutaneous oxygen tension, and claudication 
      distance. Notably, 3 months after treatment a significant increase in neovessels, 
      accompanied by complete or gradual ulcer healing, was shown in the experimental 
      group. In addition, no serious complications or adverse reactions were associated 
      with the treatment. Conclusion: Therefore, our results indicate that HUCMSC 
      transplantation after angioplasty is a safe and effective clinical therapy for 
      severe diabetic foot.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Qin, H L
AU  - Qin HL
AD  - Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical 
      University, Hefei, China.
FAU - Zhu, X H
AU  - Zhu XH
AD  - Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical 
      University, Hefei, China.
FAU - Zhang, B
AU  - Zhang B
AD  - Department of Ultrasound in Medicine, East Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Zhou, L
AU  - Zhou L
AD  - Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical 
      University, Hefei, China.
FAU - Wang, W Y
AU  - Wang WY
AD  - Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical 
      University, Hefei, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20160524
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Allografts
MH  - *Angioplasty
MH  - Diabetic Foot/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells
MH  - Middle Aged
MH  - *Umbilical Cord
EDAT- 2016/05/25 06:00
MHDA- 2017/03/04 06:00
CRDT- 2016/05/25 06:00
PHST- 2016/05/25 06:00 [pubmed]
PHST- 2017/03/04 06:00 [medline]
PHST- 2016/05/25 06:00 [entrez]
AID - 10.1055/s-0042-103684 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2016 Sep;124(8):497-503. doi: 
      10.1055/s-0042-103684. Epub 2016 May 24.