PMID- 27220658
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20220409
IS  - 1521-6551 (Electronic)
IS  - 1521-6543 (Linking)
VI  - 68
IP  - 7
DP  - 2016 Jul
TI  - Circulating serum irisin levels in obesity and type 2 diabetes mellitus.
PG  - 544-56
LID - 10.1002/iub.1511 [doi]
AB  - Irisin is an exercise-regulated myokine inducing browning of white adipose tissue 
      and has gained interest as a potential new strategy to combat obesity and its 
      associated disorders, such as type 2 diabetes mellitus (T2DM). The aim of this 
      study is to evaluate the circulating serum irisin levels in obesity and T2DM and 
      also to elucidate possible relationships between serum irisin levels with 
      anthropometric and metabolic parameters of obesity and T2DM. One hundred fifty 
      newly diagnosed T2DM patients as well as 150 nondiabetic control subjects were 
      enrolled in this study. Nondiabetic controls were then stratified according to 
      their body mass index (BMI) into three subgroups; lean, overweight, and obese. 
      Serum irisin levels were evaluated by enzyme-linked immunosorbent assay. Serum 
      irisin levels were significantly decreased in T2DM patients compared with 
      nondiabetic controls. Obese nondiabetic controls had significantly higher serum 
      irisin levels compared with lean nondiabetic controls. In both nondiabetic 
      controls and T2DM patients, serum irisin was significantly positively correlated 
      with BMI (r = 0.985, P < 0.001 and r = 0.218, P = 0.007, respectively), fat mass 
      (r = 0.959, P < 0.001 and r = 0.202, P = 0.013, respectively), fat-free mass (r = 
      0.606, P < 0.001 and r = 0.194, P = 0.017, respectively), fat-free mass index (r 
      = 0.820, P < 0.001 and r = 0.179, P = 0.028, respectively), waist-to-hip ratio (r 
      = 0.880, P < 0.001 and r = 0.194, P = 0.017, respectively), fasting insulin (r = 
      0.989, P < 0.001 and r = 0.207, P = 0.011, respectively), and HOMA-IR (r = 0.989, 
      P < 0.001 and r = 0.185, P = 0.023, respectively), whereas; significantly 
      negatively correlated with insulin sensitivity (r = -0.992, P < 0.001 and r = 
      -0.187, P = 0.022, respectively). In this study, we demonstrated that circulating 
      serum irisin levels were increased in obese nondiabetic subjects, while decreased 
      in T2DM patients. Moreover, serum irisin levels were correlated with 
      anthropometric and metabolic markers of obesity and T2DM. (c) 2016 IUBMB Life, 
      68(7):544-556, 2016.
CI  - (c) 2016 International Union of Biochemistry and Molecular Biology.
FAU - Shoukry, Amira
AU  - Shoukry A
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Shalaby, Sally M
AU  - Shalaby SM
AD  - Medical Biochimistry Department, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
FAU - El-Arabi Bdeer, Shereen
AU  - El-Arabi Bdeer S
AD  - Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
FAU - Mahmoud, Amira A
AU  - Mahmoud AA
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Mousa, Mayada M
AU  - Mousa MM
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
FAU - Khalifa, Ashraf
AU  - Khalifa A
AD  - Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20160524
PL  - England
TA  - IUBMB Life
JT  - IUBMB life
JID - 100888706
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood/genetics/pathology
MH  - Fasting
MH  - Female
MH  - Fibronectins/*blood
MH  - Humans
MH  - Insulin/blood/genetics
MH  - Insulin Resistance/genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/genetics/pathology
OTO - NOTNLM
OT  - obesity
OT  - serum irisin
OT  - type 2 diabetes mellitus
EDAT- 2016/05/26 06:00
MHDA- 2017/09/02 06:00
CRDT- 2016/05/26 06:00
PHST- 2016/03/18 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
AID - 10.1002/iub.1511 [doi]
PST - ppublish
SO  - IUBMB Life. 2016 Jul;68(7):544-56. doi: 10.1002/iub.1511. Epub 2016 May 24.