PMID- 27221555
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20160525
IS  - 1438-3276 (Print)
IS  - 1438-3276 (Linking)
VI  - 158 Suppl 4
DP  - 2016 May 25
TI  - [Insufficient symptom control under long-term treatment with PPI in GERD - fact 
      or fiction?].
PG  - 7-11
LID - 10.1007/s15006-016-8303-0 [doi]
AB  - BACKGROUND: Randomized controlled trials show that patients with gastroesophageal 
      reflux disease (GERD) and treatment with proton pump inhibitors (PPI) in about 
      30% of the cases complain about persisting reflux symptoms (heartburn, 
      regurgitation). The aim of the study was to evaluate the efficacy of PPI 
      long-term treatment in patients with GERD in the family doctor's office. METHOD: 
      Patients with GERD and a PPI therapy of at least one year participated in a 
      prospective, multicenter observational study. The patients obtained a 
      questionnaire together with a further prescription of PPI. They were asked about 
      the intensity and frequency of heartburn, regurgitation and sleep disorders due 
      to reflux symptoms, satisfaction with PPI therapy, diagnostics performed up to 
      now (endoscopy, pH monitoring, manometry) and surgical consultation. The 
      questionnaire included a validated instrument for the diagnosis of GERD (GerdQ). 
      Patients with the diagnosis "GERD " according to the questionnaire who were very 
      dissatisfied with their current PPI therapy (score 1 or 2 on a 5-point Likert 
      scale) were defined as "lost patients " (LOPA). RESULTS: 39% of the patients 
      still suffered from heartburn at least two days a week, 30% of regurgitation. In 
      22% of the patients, reflux symptoms led to sleep disorder at least two days a 
      week. 20% of the patients were very dissatisfied with the current PPI therapy. 
      70% of them (= 14% of the total patient population) were "lost patients " 
      according to the definition. An endoscopy was performed in 86% of the patients 
      and function diagnosis (pH monitoring +/- manometry) in 8%. A surgeon was consulted 
      in 8% of the patients, a third of which had received function diagnosis before. 
      CONCLUSIONS: A poor symptom control can often be found in GERD patients with PPI 
      long-term therapy, but does not stand out in the daily routine. So diagnosis will 
      not continue and treatment alternatives will not be searched for. In the future 
      quality of treatment should be verified e. g. by questionnaires.
FAU - Labenz, Joachim
AU  - Labenz J
AD  - Refluxzentrum Siegerland, Medizinische Klinik, Diakonie Klinikum GmbH, 
      Jung-Stilling-Krankenhaus, Wichernstr. 40, 57074, Siegen, Deutschland. 
      J.Labenz@t-online.de.
FAU - Labenz, Gisela
AU  - Labenz G
AD  - Refluxzentrum Siegerland, Medizinisches Zentrum am Siegerland-Flughafen, Burbach, 
      Deutschland.
FAU - Stephan, Dietmar
AU  - Stephan D
AD  - Refluxzentrum Siegerland, Chirurgische Klinik, St. Marien-Krankenhaus, Siegen, 
      Deutschland.
FAU - Willeke, Frank
AU  - Willeke F
AD  - Refluxzentrum Siegerland, Chirurgische Klinik, St. Marien-Krankenhaus, Siegen, 
      Deutschland.
CN  - LOPA-Studiengruppe
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
TT  - Unzureichende Symptomkontrolle unter Langzeittherapie mit PPI bei GERD - Fakt 
      oder Fiktion?
DEP - 20160525
PL  - Germany
TA  - MMW Fortschr Med
JT  - MMW Fortschritte der Medizin
JID - 100893959
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Gastric Acidity Determination
MH  - Gastroesophageal Reflux/diagnosis/*drug therapy
MH  - Guideline Adherence
MH  - Humans
MH  - Long-Term Care
MH  - Patient Satisfaction
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Surveys and Questionnaires
MH  - Treatment Failure
OTO - NOTNLM
OT  - gastroesophageal reflux disease (GERD)
OT  - proton pump inhibitors (PPI)
OT  - questionnaire
OT  - symptom control
EDAT- 2016/05/26 06:00
MHDA- 2016/09/14 06:00
CRDT- 2016/05/26 06:00
PHST- 2016/04/04 00:00 [received]
PHST- 2016/04/28 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
AID - 10.1007/s15006-016-8303-0 [pii]
AID - 10.1007/s15006-016-8303-0 [doi]
PST - ppublish
SO  - MMW Fortschr Med. 2016 May 25;158 Suppl 4:7-11. doi: 10.1007/s15006-016-8303-0. 
      Epub 2016 May 25.