PMID- 27222344
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20170817
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 32
IP  - 11-12
DP  - 2016 Nov-Dec
TI  - Fasting during the suckling-weaning transient period of rats induces inflammatory 
      gene expression in the adipose tissue and peripheral leukocytes.
PG  - 1268-74
LID - S0899-9007(16)30003-X [pii]
LID - 10.1016/j.nut.2016.03.011 [doi]
AB  - OBJECTIVE: Nutritional deficiency during developmental stages could be associated 
      with subsequent development of inflammation-related metabolic abnormalities. In 
      this study, we examined the effects of a 3-d fast during the suckling-weaning 
      transient period of rats, and subsequent intake of high-fat-high-sucrose (HF) and 
      low-fat-high-starch (LF) diets in adulthood, on the expression of inflammatory 
      genes in adipose tissue and peripheral leukocytes. METHODS: Male Sprague-Dawley 
      rats were deprived of food for 3 d during the suckling-weaning transient period, 
      and were subsequently fed an HF or LF diet for 14 wk from 17 wk of age. Serum 
      monocyte chemoattractant protein-1 (MCP-1) concentration and mRNA levels of 
      inflammatory genes in mesenteric adipose tissues were assessed at 31 wk of age. 
      The mRNA levels of inflammatory genes at 0 h and 2 h after oral glucose load at 
      30 wk of age in peripheral leukocytes were measured. RESULTS: Fasting induced 
      circulating MCP-1 protein in rats fed an LF diet but not an HF diet. The HF diet 
      induced high mRNA levels of tumor necrosis factor-alpha, interleukin-1beta, and S100 
      proteins in peripheral leukocytes at 2 h after glucose load in fasted rats when 
      compared with controls. Expression of CD11c, an activated macrophage marker, was 
      induced in the fasted group given an HF diet during adulthood. CONCLUSIONS: 
      Fasting rats during the suckling-weaning transient period and an HF diet intake 
      during adulthood enhance inflammation by promoting the expression of inflammatory 
      genes in adipose tissue and peripheral leukocytes.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Honma, Kazue
AU  - Honma K
AD  - Laboratory of Nutritional Physiology, Graduate School of Nutritional and 
      Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
FAU - Mawatari, Riko
AU  - Mawatari R
AD  - Laboratory of Nutritional Physiology, School of Food and Nutritional Sciences, 
      University of Shizuoka, Shizuoka, Japan.
FAU - Iikeda, Misa
AU  - Iikeda M
AD  - Laboratory of Nutritional Physiology, Graduate School of Nutritional and 
      Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
FAU - Mochizuki, Kazuki
AU  - Mochizuki K
AD  - Laboratory of Nutritional Physiology, Graduate School of Nutritional and 
      Environmental Sciences, University of Shizuoka, Shizuoka, Japan; Laboratory of 
      Food and Nutritional Sciences, Department of Local Produce and Food Sciences, 
      Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi, 
      Japan.
FAU - Goda, Toshinao
AU  - Goda T
AD  - Laboratory of Nutritional Physiology, Graduate School of Nutritional and 
      Environmental Sciences, University of Shizuoka, Shizuoka, Japan. Electronic 
      address: Gouda@u-shizuoka-ken.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20160325
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adipose Tissue/*metabolism/pathology
MH  - Animals
MH  - Animals, Suckling
MH  - Diet/adverse effects
MH  - Disease Models, Animal
MH  - Fasting/*metabolism
MH  - Gene Expression
MH  - Inflammation Mediators/*metabolism
MH  - Leukocytes/*metabolism
MH  - Male
MH  - Malnutrition/etiology/*genetics/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Weaning
OTO - NOTNLM
OT  - Adipose tissue
OT  - Inflammation
OT  - Malnutrition
OT  - Peripheral leukocyte
OT  - Suckling-weaning transient period
EDAT- 2016/05/26 06:00
MHDA- 2017/03/23 06:00
CRDT- 2016/05/26 06:00
PHST- 2015/12/18 00:00 [received]
PHST- 2016/02/21 00:00 [revised]
PHST- 2016/03/15 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
AID - S0899-9007(16)30003-X [pii]
AID - 10.1016/j.nut.2016.03.011 [doi]
PST - ppublish
SO  - Nutrition. 2016 Nov-Dec;32(11-12):1268-74. doi: 10.1016/j.nut.2016.03.011. Epub 
      2016 Mar 25.