PMID- 27222671
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160525
LR  - 20220331
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 8
IP  - 6
DP  - 2016 Jun
TI  - Oxidative Stress Measurement and Prediction of Epileptic Seizure in Children and 
      Adults With Severe Motor and Intellectual Disabilities.
PG  - 437-44
LID - 10.14740/jocmr2534w [doi]
AB  - BACKGROUND: The medical care of severe motor and intellectual disabilities (SMID) 
      depends on the empirical medical care. Epileptic seizure specific to SMID is 
      difficult to suppress using anti-epileptic drugs, and its tendency to persist for 
      long periods poses an issue. The present study was undertaken to evaluate the 
      relationship between epileptic seizure in cases with SMID and oxidative stress in 
      the living body by examining endogenous antioxidants, the degree of oxidation 
      (reactive oxygen metabolites (d-ROMs)), and the biological antioxidant potential 
      (BAP) as indicators. METHODS: Target patients were 43 SMID epilepsy patients. 
      Blood was sampled before breakfast and medication. As for the specimen, d-ROMs 
      and BAP were measured using the free radical analyzer. RESULTS: The present study 
      did not reveal any correlation between endogenous antioxidants (albumin) and the 
      frequency of epileptic seizures. On the other hand, d-ROMs were correlated with 
      the frequency of epileptic seizure. In particular, strong correlations between 
      the frequency of epileptic seizures and the d-ROMs/BAP ratio as well as the 
      BAP/d-ROMs ratio were noted. CONCLUSIONS: These results indicate that the use of 
      d-ROMs and BAP as biomarkers can provide a tool for predicting the prognosis of 
      epileptic seizures in patients with SMID.
FAU - Morimoto, Masahito
AU  - Morimoto M
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan; Japanese Red Cross Tokushima Hinomine Rehabilitation Center for 
      People With Disabilities, Tokushima, Japan.
FAU - Satomura, Shigeko
AU  - Satomura S
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People With 
      Disabilities, Tokushima, Japan.
FAU - Hashimoto, Toshiaki
AU  - Hashimoto T
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People With 
      Disabilities, Tokushima, Japan.
FAU - Ito, Etsuro
AU  - Ito E
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
FAU - Kyotani, Shojiro
AU  - Kyotani S
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160525
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC4852776
OTO - NOTNLM
OT  - Biomarker
OT  - Epilepsy
OT  - Motor and intellectual disabilities
OT  - Oxidative stress
OT  - Seizure
OT  - d-ROMs test
EDAT- 2016/05/26 06:00
MHDA- 2016/05/26 06:01
PMCR- 2016/05/25
CRDT- 2016/05/26 06:00
PHST- 2016/03/22 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2016/05/26 06:01 [medline]
PHST- 2016/05/25 00:00 [pmc-release]
AID - 10.14740/jocmr2534w [doi]
PST - ppublish
SO  - J Clin Med Res. 2016 Jun;8(6):437-44. doi: 10.14740/jocmr2534w. Epub 2016 May 25.