PMID- 27223481
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20170417
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 64
IP  - 24
DP  - 2016 Jun 22
TI  - Selenium-Containing Phycocyanin from Se-Enriched Spirulina platensis Reduces 
      Inflammation in Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB 
      Activation.
PG  - 5060-70
LID - 10.1021/acs.jafc.6b01308 [doi]
AB  - Selenium (Se) plays an important role in fine-tuning immune responses. 
      Inflammatory bowel disease (IBD) involves hyperresponsive immunity of the 
      digestive tract, and a low Se level might aggravate IBD progression; however, the 
      beneficial effects of natural Se-enriched diets on IBD remain unknown. 
      Previously, we developed high-yield Se-enriched Spirulina platensis (Se-SP) as an 
      excellent organic nutritional Se source. Here we prepared Se-containing 
      phycocyanin (Se-PC) from Se-SP and observed that Se-PC administration effectively 
      reduced the extent of colitis in mouse induced by dextran sulfate sodium. 
      Supplementation with Se-PC resulted in significant protective effects, including 
      mitigation of body weight loss, bloody diarrhea, and colonic inflammatory damage. 
      The anti-inflammatory effects of Se-PC supplementation were found to involve 
      modulation of cytokines, including IL-6, TNF-alpha, MCP-1, and IL-10. 
      Mechanistically, Se-PC inhibited the activation of macrophages by suppressing the 
      nuclear translocation of NF-kappaB, which is involved in the transcription of these 
      pro-inflammatory cytokines. These results together suggest potential benefits of 
      Se-PC as a functional Se supplement to reduce the symptoms of IBD.
FAU - Zhu, Chenghui
AU  - Zhu C
AD  - College of Pharmacy, Jinan University , Guangzhou 510632, Guangdong Province, 
      China.
FAU - Ling, Qinjie
AU  - Ling Q
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
FAU - Cai, Zhihui
AU  - Cai Z
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
FAU - Wang, Yun
AU  - Wang Y
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
FAU - Zhang, Yibo
AU  - Zhang Y
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
FAU - Hoffmann, Peter R
AU  - Hoffmann PR
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
AD  - Department of Cell and Molecular Biology, John A. Burns School of Medicine, 
      University of Hawaii , Honolulu, Hawaii 96813, United States.
FAU - Zheng, Wenjie
AU  - Zheng W
AD  - Department of Chemistry, School of Life Science and Technology, Jinan University 
      , Guangzhou 510632, Guangdong Province, China.
FAU - Zhou, Tianhong
AU  - Zhou T
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
FAU - Huang, Zhi
AU  - Huang Z
AD  - Department of Biotechnology, School of Life Science and Technology, Jinan 
      University , Guangzhou 510632, Guangdong Province, China.
LA  - eng
PT  - Journal Article
DEP - 20160607
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11016-15-2 (Phycocyanin)
RN  - 130068-27-8 (Interleukin-10)
RN  - 9042-14-2 (Dextran Sulfate)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Colitis/chemically induced/*drug therapy/genetics/immunology
MH  - Dextran Sulfate/adverse effects
MH  - Humans
MH  - Interleukin-10/genetics/immunology
MH  - Interleukin-6/genetics/immunology
MH  - Macrophages/drug effects/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/genetics/immunology
MH  - Phycocyanin/*administration & dosage/analysis
MH  - Selenium/*analysis
MH  - Spirulina/*chemistry
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
OTO - NOTNLM
OT  - IBD
OT  - NF-kappaB pathway
OT  - Spirulina platensis
OT  - phycocyanin
OT  - selenium
EDAT- 2016/05/26 06:00
MHDA- 2017/04/18 06:00
CRDT- 2016/05/26 06:00
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
AID - 10.1021/acs.jafc.6b01308 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2016 Jun 22;64(24):5060-70. doi: 10.1021/acs.jafc.6b01308. 
      Epub 2016 Jun 7.