PMID- 27223631
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20220311
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 43
DP  - 2016 Sep
TI  - Polymorphisms on IFNG, IL12B and IL12RB1 genes and paracoccidioidomycosis in the 
      Brazilian population.
PG  - 245-51
LID - S1567-1348(16)30197-6 [pii]
LID - 10.1016/j.meegid.2016.05.025 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic chronic mycosis, endemic in Latin 
      America, especially Brazil, and is the eighth leading cause of death among 
      chronic and recurrent infectious diseases. PCM infection is characterized by the 
      presence of Th1 immune response; the acute form, by a mixed Th2/Th9, while the 
      chronic form is characterized by Th17/Th22 profiles. The occurrence and severity 
      of human PCM may also be associated with genetic factors such as single 
      nucleotide polymorphisms (SNP) on cytokines encoding genes. We investigated the 
      association between these polymorphisms and the different clinical forms of PCM. 
      We included 156 patients with PCM (40 with the acute form, 99 with the chronic 
      multifocal and 17 with the chronic unifocal form) and assayed their DNA samples 
      for IFNG +874 T/A SNP by PCR-ARMS (Amplification Refractory Mutational System), 
      IL12B +1188 A/C SNP on 3' UTR and IL12RB1 641 A/G SNP on exon 7 by PCR-RFLP 
      (Restriction Fragment Length Polymorphism). We found similar genotypic and 
      allelic frequencies of the investigated SNPs among the clinical forms of PCM. 
      Considering male patients, the IL12RB1 641 AA genotype was more frequent in the 
      chronic multifocal form while heterozygosis was in the chronic unifocal form of 
      PCM (p=0.048). Although our data suggest that the AA genotype (IL12RB1) may be 
      associated with the more disseminated chronic disease, more patients of the 
      chronic unifocal PCM group need to be analyzed as well as the secretion patterns 
      of IFN-gamma combined with the IL-12Rbeta1 expression for a better comprehension of this 
      association.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Carvalho, F M C
AU  - Carvalho FM
AD  - Department of Infectious and Parasitic Diseases, Faculdade de Medicina, 
      Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 (IMT1, 1 degrees . 
      andar), 05403-000 Sao Paulo, SP, Brazil; Laboratory of Medical Investigation in 
      Immunology (LIM-48), Hospital das Clinicas, Faculdade de Medicina, Universidade 
      de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 (IMT2, terreo, sala 12), 
      05403-000 Sao Paulo, SP, Brazil. Electronic address: flavinhamch@gmail.com.
FAU - Busser, F D
AU  - Busser FD
AD  - Laboratory of Medical Investigation in Immunology (LIM-48), Hospital das 
      Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Eneas de 
      Carvalho Aguiar, 470 (IMT2, terreo, sala 12), 05403-000 Sao Paulo, SP, Brazil. 
      Electronic address: felipe_db89@hotmail.com.
FAU - Freitas, V L T
AU  - Freitas VL
AD  - Laboratory of Medical Investigation in Immunology (LIM-48), Hospital das 
      Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Eneas de 
      Carvalho Aguiar, 470 (IMT2, terreo, sala 12), 05403-000 Sao Paulo, SP, Brazil. 
      Electronic address: vera_lucia@yahoo.com.
FAU - Furucho, C R
AU  - Furucho CR
AD  - Laboratory of Medical Investigation in Immunology (LIM-48), Hospital das 
      Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Eneas de 
      Carvalho Aguiar, 470 (IMT2, terreo, sala 12), 05403-000 Sao Paulo, SP, Brazil. 
      Electronic address: celiarf@usp.br.
FAU - Sadahiro, A
AU  - Sadahiro A
AD  - Department of Parasitology, Instituto de Ciencias Biologicas, Universidade 
      Federal do Amazonas, Av. General Rodrigo Octavio, 6200, Coroado 69077-000, 
      Amazonas, Brazil. Electronic address: asadahiro@ufam.edu.br.
FAU - Kono, A S G
AU  - Kono AS
AD  - Infectious Diseases Division, Hospital das Clinicas, Universidade de Sao Paulo, 
      Av. Dr. Eneas de Carvalho Aguiar, 155 (5 degrees . andar, Bloco 2A), 05403-000 Sao Paulo, 
      SP, Brazil. Electronic address: adriana.kono@uol.com.br.
FAU - Criado, P R
AU  - Criado PR
AD  - Dermatological Clinic Division, Hospital das Clinicas, Universidade de Sao Paulo, 
      Av. Dr. Eneas de Carvalho Aguiar, 255 (5 degrees . andar, Bloco 2B), 05403-000 Sao Paulo, 
      SP, Brazil. Electronic address: prcriado@usp.br.
FAU - Moretti, M L
AU  - Moretti ML
AD  - Hospital das Clinicas, Faculdade de Ciencias Medicas, Universidade Estadual de 
      Campinas, Rua Vital Brasil, 251, Cidade Universitaria, 13083-888, Campinas, SP, 
      Sao Paulo, Brazil. Electronic address: moretti@hc.unicamp.br.
FAU - Sato, P K
AU  - Sato PK
AD  - Department of Infectious and Parasitic Diseases, Faculdade de Medicina, 
      Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 (IMT1, 1 degrees . 
      andar), 05403-000 Sao Paulo, SP, Brazil; Laboratory of Medical Investigation in 
      Immunology (LIM-48), Hospital das Clinicas, Faculdade de Medicina, Universidade 
      de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 (IMT2, terreo, sala 12), 
      05403-000 Sao Paulo, SP, Brazil. Electronic address: paulaksato@yahoo.com.
FAU - Shikanai-Yasuda, M A
AU  - Shikanai-Yasuda MA
AD  - Department of Infectious and Parasitic Diseases, Faculdade de Medicina, 
      Universidade de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 (IMT1, 1 degrees . 
      andar), 05403-000 Sao Paulo, SP, Brazil; Laboratory of Medical Investigation in 
      Immunology (LIM-48), Hospital das Clinicas, Faculdade de Medicina, Universidade 
      de Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 (IMT2, terreo, sala 12), 
      05403-000 Sao Paulo, SP, Brazil. Electronic address: maria.shikanai@hc.fm.usp.br.
LA  - eng
PT  - Journal Article
DEP - 20160517
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (3' Untranslated Regions)
RN  - 0 (IFNG protein, human)
RN  - 0 (IL12B protein, human)
RN  - 0 (IL12RB1 protein, human)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 0 (Receptors, Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Brazil
MH  - Child
MH  - Chronic Disease
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - Genotype
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Interferon-gamma/*genetics/immunology
MH  - Interleukin-12 Subunit p40/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioides/growth & development
MH  - Paracoccidioidomycosis/*genetics/immunology/microbiology/pathology
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-12/*genetics/immunology
MH  - Sex Factors
OTO - NOTNLM
OT  - Cytokines
OT  - IFNG, IL12B
OT  - IL12RB1
OT  - Paracoccidioidomycosis
OT  - SNP
EDAT- 2016/05/26 06:00
MHDA- 2017/10/03 06:00
CRDT- 2016/05/26 06:00
PHST- 2016/02/15 00:00 [received]
PHST- 2016/04/07 00:00 [revised]
PHST- 2016/05/17 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
AID - S1567-1348(16)30197-6 [pii]
AID - 10.1016/j.meegid.2016.05.025 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2016 Sep;43:245-51. doi: 10.1016/j.meegid.2016.05.025. Epub 
      2016 May 17.