PMID- 27224073
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20190221
IS  - 1678-2925 (Electronic)
IS  - 0004-2749 (Linking)
VI  - 79
IP  - 2
DP  - 2016 Apr
TI  - Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma 
      patients.
PG  - 100-4
LID - S0004-27492016000200100 [pii]
LID - 10.5935/0004-2749.20160030 [doi]
AB  - PURPOSE: To assess cognitive performance differences among primary open-angle 
      glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy 
      control (C) subjects. METHODS: A total of 60 participants (20 POAG, 20 NTG, and 
      20 C subjects) were included in this study. A detailed ophthalmologic examination 
      was performed on all participants. A spectral domain-optical coherence tomography 
      (SD-OCT) system was used to measure the ganglion cell-inner plexiform layer 
      (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses. To assess the 
      cognitive performance of all participants, detailed neurological examinations, 
      including the mini-mental state examination (MMSE), were performed by the same 
      neurologist. RESULTS: There were no significant differences among the groups in 
      terms of age (p =0.348) or gender (p =0.935). The mean RNFL thicknesses were 
      significantly different among the groups (85.2 +/- 14.7, 76.8 +/- 10.3, and 91.4 +/- 
      7.7 microm in the POAG, NTG, and C subjects, respectively; p <0.001). The mean GC-IPL 
      thicknesses were 77.5 +/- 9.7 microm in the POAG group, 73.4 +/- 7.8 microm in the NTG group, 
      and 78.8 +/- 3.8 microm in the C group. Differences among the groups were not 
      statistically significant (p =0.085). MMSE scores were 26.1 +/- 1.4, 25.7 +/- 2.3, 
      and 28.8 +/- 0.9 in the POAG, NTG, and C groups, respectively. There were 
      significant differences among the three groups (p <0.001). Specifically, there 
      were significant differences between the NTG and C groups (p <0.001), and between 
      the POAG and C groups (p =0.001). There was no significant difference between the 
      POAG and NTG groups (p =0.595). CONCLUSIONS: There appear to be similar risk 
      factors in glaucoma and neurodegenerative disorders that cause deterioration in 
      cognitive performance. Comparing the low MMSE scores of the POAG and NTG patients 
      with the scores of healthy C participants supports our hypothesis. Consequently, 
      it is recommended that a neurologist should also examine glaucoma patients.
FAU - Bulut, Mehmet
AU  - Bulut M
AD  - Ophthalmology Department, Antalya Training and Research Hospital, Antalya, 
      Turkey.
FAU - Yaman, Aylin
AU  - Yaman A
AD  - Neurology Department, Antalya Training and Research Hospital, Antalya, Turkey.
FAU - Erol, Muhammet Kazim
AU  - Erol MK
AD  - Ophthalmology Department, Antalya Training and Research Hospital, Antalya, 
      Turkey.
FAU - Kurtulus, Fatma
AU  - Kurtulus F
AD  - Neurology Department, Antalya Training and Research Hospital, Antalya, Turkey.
FAU - Toslak, Devrim
AU  - Toslak D
AD  - Ophthalmology Department, Antalya Training and Research Hospital, Antalya, 
      Turkey.
FAU - Coban, Deniz Turgut
AU  - Coban DT
AD  - Ophthalmology Department, Antalya Training and Research Hospital, Antalya, 
      Turkey.
FAU - Basar, Ebru Kaya
AU  - Basar EK
AD  - Department of Animal Science Biometry and Genetics Unit, Faculty of Agriculture, 
      Akdeniz University, Akdeniz, Turkey.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Oftalmol
JT  - Arquivos brasileiros de oftalmologia
JID - 0400645
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - *Cognition
MH  - Dementia/diagnosis/physiopathology
MH  - Female
MH  - *Glaucoma, Open-Angle
MH  - Humans
MH  - *Low Tension Glaucoma
MH  - Male
MH  - Mental Status Schedule/*statistics & numerical data
MH  - Middle Aged
MH  - Nerve Fibers/physiology
MH  - Retina/anatomy & histology/physiopathology
MH  - Retinal Ganglion Cells/physiology
MH  - Tomography, Optical Coherence/methods
EDAT- 2016/05/26 06:00
MHDA- 2017/05/02 06:00
CRDT- 2016/05/26 06:00
PHST- 2015/08/24 00:00 [received]
PHST- 2016/01/07 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
AID - S0004-27492016000200100 [pii]
AID - 10.5935/0004-2749.20160030 [doi]
PST - ppublish
SO  - Arq Bras Oftalmol. 2016 Apr;79(2):100-4. doi: 10.5935/0004-2749.20160030.