PMID- 27224442
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 21
IP  - 4
DP  - 2016 Aug
TI  - Auto- and allo-epitopes in DQ alloreactive antibodies.
PG  - 355-61
LID - 10.1097/MOT.0000000000000327 [doi]
AB  - PURPOSE OF REVIEW: Significant interest is now focused on deciphering human 
      leukocyte antigen (HLA) epitopes and the utilization of this new knowledge to 
      improve donor-recipient matching in transplantation. A recently introduced 
      concept is the appearance of antibodies against what may be considered as 
      self-epitopes, including the introduction of the 'nonself-self paradigm'. RECENT 
      FINDINGS: Common practice in analyzing HLA-DQ antibodies have been to separate 
      between antibodies against the alpha chain and antibodies against the beta chain of the 
      molecule. This is despite the fact that the two chains have to intertwine 
      together to be expressed stably on the cell surface. We have previously provided 
      evidence that this practice is false. We further provide evidence to refute the 
      use of 'self-epitopes' as an immunologically feasible terminology by delineating 
      the historic events leading to today's misconceptions. SUMMARY: The evidence we 
      present supports the need for a change in current practices. HLA-DQ antigens and 
      antibodies should be viewed as combined DQalpha/beta complexes. This will have impact to 
      assigning cPRA value, assigning acceptable and unacceptable antigens, and pave 
      the way to a better understanding of true HLA epitopes as we strive to improve 
      donor--recipient compatibility and minimize generation of de-novo HLA antibodies.
FAU - Tambur, Anat R
AU  - Tambur AR
AD  - Comprehensive Transplant Center, Northwestern University, Chicago, Illinois, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Epitopes)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Amino Acid Sequence
MH  - Epitopes/*immunology
MH  - HLA-DQ Antigens/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Molecular Sequence Data
EDAT- 2016/05/26 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/05/26 06:00
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1097/MOT.0000000000000327 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2016 Aug;21(4):355-61. doi: 
      10.1097/MOT.0000000000000327.