PMID- 27224647
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20220318
IS  - 1873-6246 (Electronic)
IS  - 0301-0511 (Linking)
VI  - 118
DP  - 2016 Jul
TI  - A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity.
PG  - 88-93
LID - S0301-0511(16)30184-3 [pii]
LID - 10.1016/j.biopsycho.2016.05.005 [doi]
AB  - We sought to determine whether oxidative stress and anti-oxidative activity could 
      act as biomarkers that discriminate patients with chronic fatigue syndrome (CFS) 
      from healthy volunteers at acute and sub-acute fatigue and resting conditions. We 
      calculated the oxidative stress index (OSI) from reactive oxygen 
      metabolites-derived compounds (d-ROMs) and the biological antioxidant potential 
      (BAP). We determined changes in d-ROMs, BAP, and OSI in acute and sub-acute 
      fatigue in two healthy groups, and compared their values at rest between patients 
      with CFS (diagnosed by Fukuda 1994 criteria) and another group of healthy 
      controls. Following acute fatigue in healthy controls, d-ROMs and OSI increased, 
      and BAP decreased. Although d-ROMs and OSI were significantly higher after 
      sub-acute fatigue, BAP did not decrease. Resting condition yielded higher d-ROMs, 
      higher OSI, and lower BAP in patients with CFS than in healthy volunteers, but 
      lower d-ROMs and OSI when compared with sub-acute controls. BAP values did not 
      significantly differ between patients with CFS and controls in the sub-acute 
      condition. However, values were significantly higher than in the resting 
      condition for controls. Thus, measured of oxidative stress (d-ROMS) and 
      anti-oxidative activity (BAP) might be useful for discriminating acute, 
      sub-acute, and resting fatigue in healthy people from patients with CFS, or for 
      evaluating fatigue levels in healthy people.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Fukuda, Sanae
AU  - Fukuda S
AD  - University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan; RIKEN 
      Center for Life Science Technologies, Kobe, Hyogo 650-0047, Japan; Department of 
      Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, 
      Japan. Electronic address: sfukuda@fuksi-kagk-u.ac.jp.
FAU - Nojima, Junzo
AU  - Nojima J
AD  - Department of Laboratory Science, Yamaguchi University Graduate School of 
      Medicine, Yamaguchi 755-8505, Japan.
FAU - Motoki, Yukari
AU  - Motoki Y
AD  - Department of Laboratory Science, Yamaguchi University Graduate School of 
      Medicine, Yamaguchi 755-8505, Japan.
FAU - Yamaguti, Kouzi
AU  - Yamaguti K
AD  - Department of Physiology, Osaka City University Graduate School of Medicine, 
      Osaka 545-8585, Japan; Department of Endocrinology, Metabolism and Molecular 
      Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, 
      Japan.
FAU - Nakatomi, Yasuhito
AU  - Nakatomi Y
AD  - Department of Physiology, Osaka City University Graduate School of Medicine, 
      Osaka 545-8585, Japan; Department of Endocrinology, Metabolism and Molecular 
      Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, 
      Japan.
FAU - Okawa, Naoko
AU  - Okawa N
AD  - University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan.
FAU - Fujiwara, Kazumi
AU  - Fujiwara K
AD  - University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan.
FAU - Watanabe, Yasuyoshi
AU  - Watanabe Y
AD  - RIKEN Center for Life Science Technologies, Kobe, Hyogo 650-0047, Japan; 
      Department of Physiology, Osaka City University Graduate School of Medicine, 
      Osaka 545-8585, Japan.
FAU - Kuratsune, Hirohiko
AU  - Kuratsune H
AD  - University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan; RIKEN 
      Center for Life Science Technologies, Kobe, Hyogo 650-0047, Japan; Department of 
      Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, 
      Japan; Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Osaka 545-8585, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20160517
PL  - Netherlands
TA  - Biol Psychol
JT  - Biological psychology
JID - 0375566
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Antioxidants/*metabolism
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Fatigue Syndrome, Chronic/blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/*blood
OTO - NOTNLM
OT  - Anti-oxidative activity
OT  - Fatigue
OT  - Oxidative stress
EDAT- 2016/05/26 06:00
MHDA- 2017/09/07 06:00
CRDT- 2016/05/26 06:00
PHST- 2015/07/17 00:00 [received]
PHST- 2016/03/01 00:00 [revised]
PHST- 2016/05/15 00:00 [accepted]
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
AID - S0301-0511(16)30184-3 [pii]
AID - 10.1016/j.biopsycho.2016.05.005 [doi]
PST - ppublish
SO  - Biol Psychol. 2016 Jul;118:88-93. doi: 10.1016/j.biopsycho.2016.05.005. Epub 2016 
      May 17.