PMID- 27224743
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20181202
IS  - 1531-6963 (Electronic)
IS  - 1040-8711 (Linking)
VI  - 28
IP  - 4
DP  - 2016 Jul
TI  - Proton pump inhibitors and osteoporosis.
PG  - 420-5
LID - 10.1097/BOR.0000000000000291 [doi]
AB  - PURPOSE OF REVIEW: The purpose of the review is to provide an update on recent 
      advances in the evidence based on proton pump inhibitors (PPI) as a possible 
      cause of osteoporosis and osteoporotic fractures. This review focuses, in 
      particular, on new studies published in the last 18 months and a discussion of 
      these findings and how this has influenced our understanding of this association, 
      the clinical impact and the underlying pathophysiology. RECENT FINDINGS: New 
      studies have further strengthened existing evidence linking use of PPIs to 
      osteoporosis. Short-term use does not appear to pose a lower risk than long-term 
      use. There is a continued lack of conclusive studies identifying the 
      pathogenesis. Direct effects on calcium absorption or on osteoblast or osteoclast 
      action cannot at present plausibly explain the mechanism. SUMMARY: The use of 
      PPIs is a risk factor for development of osteoporosis and osteoporotic fractures. 
      However, as the direct pathogenesis remains unclear, specific points of 
      intervention are lacking, other than being vigilant in regard to the indication 
      for prescribing PPIs and to use the lowest effective dose where PPIs cannot be 
      avoided.
FAU - Andersen, Bjarne Nesgaard
AU  - Andersen BN
AD  - aDepartment of Medicine, Holbaek Hospital, HolbaekbOdense Patient Data Explorative 
      Network, University of Southern Denmark, Odense, Denmark.
FAU - Johansen, Per Birger
AU  - Johansen PB
FAU - Abrahamsen, Bo
AU  - Abrahamsen B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Bone Density/drug effects
MH  - Drug Prescriptions/standards
MH  - Humans
MH  - Osteoporosis/*chemically induced
MH  - Osteoporotic Fractures/chemically induced
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Risk Factors
EDAT- 2016/05/26 06:00
MHDA- 2017/06/01 06:00
CRDT- 2016/05/26 06:00
PHST- 2016/05/26 06:00 [entrez]
PHST- 2016/05/26 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
AID - 00002281-201607000-00013 [pii]
AID - 10.1097/BOR.0000000000000291 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2016 Jul;28(4):420-5. doi: 10.1097/BOR.0000000000000291.