PMID- 27225263
OWN - NLM
STAT- MEDLINE
DCOM- 20170202
LR  - 20221207
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 95
IP  - 8
DP  - 2016 Aug
TI  - The prevalence of chromosomal aberrations associated with myelodysplastic 
      syndromes in China.
PG  - 1241-8
LID - 10.1007/s00277-016-2698-7 [doi]
AB  - This study aims to investigate the prevalence and distribution of diverse 
      chromosomal aberrations associated with myelodysplastic syndromes (MDS) in China. 
      Bone marrow samples were collected from multiple cities in China. Metaphase 
      cytogenetic (MC) analysis and fluorescence in situ hybridization (FISH) were 
      initially used to test chromosomal lesions. Affymetrix CytoScan 750 K genechip 
      platform performed a genome-wide detection of chromosomal aberrations. 
      Chromosomal gain was identified in 76 patients; the most prevalent was trisomy 
      8(17.9 %). New chromosomal gain was detected on chromosome 9, 19p, and X. 
      Chromosomal loss was detected in 101 patients. The most frequent was loss 5q 
      (21.0 %). Some loss and gain were not identified by MC or FISH but identified by 
      genechip. UPD was solely identified by genechip in 51 patients; the most 
      prevalent were UPD 7q (4.94 %) and UPD 17p (4.32 %). Furthermore, complex 
      chromosomal aberrations were detected in 56 patients. In conclusion, Affymetrix 
      CytoScan 750 K genechip was more precise than MC and FISH in detection of cryptic 
      chromosomal aberrations relevant to MDS. Analysis of the prevalence and 
      distribution of diverse chromosomal aberrations in China may improve strategies 
      for MDS diagnosis and therapies.
FAU - Hu, Qinyong
AU  - Hu Q
AD  - Department of Oncology I, Renmin Hospital, Wuhan University, Road No. 9, Wuhan, 
      China.
FAU - Chu, Yuxin
AU  - Chu Y
AD  - Department of Oncology I, Renmin Hospital, Wuhan University, Road No. 9, Wuhan, 
      China.
FAU - Song, Qibin
AU  - Song Q
AD  - Department of Oncology I, Renmin Hospital, Wuhan University, Road No. 9, Wuhan, 
      China. qibinsong@163.com.
FAU - Yao, Yi
AU  - Yao Y
AD  - Department of Oncology I, Renmin Hospital, Wuhan University, Road No. 9, Wuhan, 
      China.
FAU - Yang, Weihong
AU  - Yang W
AD  - Department of Molecular Diagnosis, Kindstar Global, Biolake B3-1, Wuhan, China.
FAU - Huang, Shiang
AU  - Huang S
AD  - Department of Molecular Diagnosis, Kindstar Global, Biolake B3-1, Wuhan, China. 
      sahuang@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160525
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - China/epidemiology
MH  - *Chromosome Aberrations
MH  - Female
MH  - Genome, Human/*genetics
MH  - Genome-Wide Association Study/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/diagnosis/ethnology/*genetics
MH  - Prevalence
MH  - Young Adult
OTO - NOTNLM
OT  - Chromosomal aberration
OT  - Genechip
OT  - Myelodysplastic syndrome (MDS)
OT  - Prevalence
EDAT- 2016/05/27 06:00
MHDA- 2017/02/06 06:00
CRDT- 2016/05/27 06:00
PHST- 2015/11/26 00:00 [received]
PHST- 2016/05/16 00:00 [accepted]
PHST- 2016/05/27 06:00 [entrez]
PHST- 2016/05/27 06:00 [pubmed]
PHST- 2017/02/06 06:00 [medline]
AID - 10.1007/s00277-016-2698-7 [pii]
AID - 10.1007/s00277-016-2698-7 [doi]
PST - ppublish
SO  - Ann Hematol. 2016 Aug;95(8):1241-8. doi: 10.1007/s00277-016-2698-7. Epub 2016 May 
      25.