PMID- 27225945
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 311
IP  - 1
DP  - 2016 Jul 1
TI  - Gene by environmental interactions affecting oxidative phosphorylation and 
      thermal sensitivity.
PG  - R157-65
LID - 10.1152/ajpregu.00008.2016 [doi]
AB  - The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic 
      ATP production and is the only metabolic pathway with proteins encoded by both 
      nuclear and mitochondrial genomes. In studies examining mitonuclear interactions 
      among distant populations within a species or across species, the interactions 
      between these two genomes can affect metabolism, growth, and fitness, depending 
      on the environment. However, there is little data on whether these interactions 
      impact natural populations within a single species. In an admixed Fundulus 
      heteroclitus population with northern and southern mitochondrial haplotypes, 
      there are significant differences in allele frequencies associated with 
      mitochondrial haplotype. In this study, we investigate how mitochondrial 
      haplotype and any associated nuclear differences affect six OxPhos parameters 
      within a population. The data demonstrate significant OxPhos functional 
      differences between the two mitochondrial genotypes. These differences are most 
      apparent when individuals are acclimated to high temperatures with the southern 
      mitochondrial genotype having a large acute response and the northern 
      mitochondrial genotype having little, if any acute response. Furthermore, acute 
      temperature effects and the relative contribution of Complex I and II depend on 
      acclimation temperature: when individuals are acclimated to 12 degrees C, the relative 
      contribution of Complex I increases with higher acute temperatures, whereas at 
      28 degrees C acclimation, the relative contribution of Complex I is unaffected by acute 
      temperature change. These data demonstrate a complex gene by environmental 
      interaction affecting the OxPhos pathway.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Baris, Tara Z
AU  - Baris TZ
AD  - Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Sciences, 
      University of Miami, Miami, Florida;
FAU - Blier, Pierre U
AU  - Blier PU
AD  - Department de Biologie, Universite du Quebec a Rimouski, Rimouski, Quebec, 
      Canada; and.
FAU - Pichaud, Nicolas
AU  - Pichaud N
AD  - Department de Biologie, Universite du Quebec a Rimouski, Rimouski, Quebec, 
      Canada; and Department of Chemistry and Biochemistry, Universite de Moncton, 
      Moncton, New Brunswick, Canada.
FAU - Crawford, Douglas L
AU  - Crawford DL
AUID- ORCID: 0000-0002-6239-4012
AD  - Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Sciences, 
      University of Miami, Miami, Florida; dcrawford@rsmas.miami.edu.
FAU - Oleksiak, Marjorie F
AU  - Oleksiak MF
AD  - Marine Biology and Ecology, Rosenstiel School of Marine and Atmospheric Sciences, 
      University of Miami, Miami, Florida;
LA  - eng
PT  - Journal Article
DEP - 20160525
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 9007-43-6 (Cytochromes c)
RN  - EC 1.3.5.1 (Electron Transport Complex II)
RN  - EC 7.1.1.2 (Electron Transport Complex I)
SB  - IM
MH  - Acclimatization/*genetics/physiology
MH  - Alleles
MH  - Animals
MH  - Body Weight
MH  - Cytochromes c/metabolism
MH  - Electron Transport Complex I/genetics/metabolism
MH  - Electron Transport Complex II/genetics/metabolism
MH  - Fundulidae/*physiology
MH  - Gene Frequency
MH  - *Gene-Environment Interaction
MH  - Genotype
MH  - Linear Models
MH  - Mitochondria/genetics/metabolism
MH  - *Oxidative Phosphorylation
MH  - Species Specificity
MH  - Temperature
OTO - NOTNLM
OT  - Fundulus heteroclitus
OT  - epistasis
OT  - metabolism
OT  - mitochondria
OT  - thermal performance
EDAT- 2016/05/27 06:00
MHDA- 2017/07/25 06:00
CRDT- 2016/05/27 06:00
PHST- 2016/01/06 00:00 [received]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/05/27 06:00 [entrez]
PHST- 2016/05/27 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
AID - ajpregu.00008.2016 [pii]
AID - 10.1152/ajpregu.00008.2016 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R157-65. doi: 
      10.1152/ajpregu.00008.2016. Epub 2016 May 25.