PMID- 27226450
OWN - NLM
STAT- MEDLINE
DCOM- 20170908
LR  - 20181113
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 116
IP  - 3
DP  - 2016 Sep 1
TI  - A combined TMS-EEG study of short-latency afferent inhibition in the motor and 
      dorsolateral prefrontal cortex.
PG  - 938-48
LID - 10.1152/jn.00260.2016 [doi]
AB  - Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) 
      enables noninvasive neurophysiological investigation of the human cortex. A TMS 
      paradigm of short-latency afferent inhibition (SAI) is characterized by 
      attenuation of the motor-evoked potential (MEP) and modulation of N100 of the 
      TMS-evoked potential (TEP) when TMS is delivered to motor cortex (M1) following 
      median nerve stimulation. SAI is a marker of cholinergic activity in the motor 
      cortex; however, the SAI has not been tested from the prefrontal cortex. We aimed 
      to explore the effect of SAI in dorsolateral prefrontal cortex (DLPFC). SAI was 
      examined in 12 healthy subjects with median nerve stimulation and TMS delivered 
      to M1 and DLPFC at interstimulus intervals (ISIs) relative to the individual N20 
      latency. SAI in M1 was tested at the optimal ISI of N20 + 2 ms. SAI in DLPFC was 
      investigated at a range of ISI from N20 + 2 to N20 + 20 ms to explore its 
      temporal profile. For SAI in M1, the attenuation of MEP amplitude was correlated 
      with an increase of TEP N100 from the left central area. A similar spatiotemporal 
      neural signature of SAI in DLPFC was observed with a marked increase of N100 
      amplitude. SAI in DLPFC was maximal at ISI N20 + 4 ms at the left frontal area. 
      These findings establish the neural signature of SAI in DLPFC. Future studies 
      could explore whether DLPFC-SAI is neurophysiological marker of cholinergic 
      dysfunction in cognitive disorders.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Noda, Yoshihiro
AU  - Noda Y
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of 
      Toronto, Toronto, Ontario, Canada; and.
FAU - Cash, Robin F H
AU  - Cash RF
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Division of Neurology, Department of 
      Medicine, University of Toronto, Division of Brain, Imaging and Behaviour-Systems 
      Neuroscience, Toronto Western Research Institute, University Health Network, 
      Toronto, Ontario, Canada.
FAU - Zomorrodi, Reza
AU  - Zomorrodi R
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada;
FAU - Dominguez, Luis Garcia
AU  - Dominguez LG
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada;
FAU - Farzan, Faranak
AU  - Farzan F
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research 
      Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 
      Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and.
FAU - Rajji, Tarek K
AU  - Rajji TK
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research 
      Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 
      Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and.
FAU - Barr, Mera S
AU  - Barr MS
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research 
      Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 
      Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and.
FAU - Chen, Robert
AU  - Chen R
AD  - Division of Neurology, Department of Medicine, University of Toronto, Division of 
      Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research 
      Institute, University Health Network, Toronto, Ontario, Canada.
FAU - Daskalakis, Zafiris J
AU  - Daskalakis ZJ
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research 
      Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 
      Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and.
FAU - Blumberger, Daniel M
AU  - Blumberger DM
AD  - Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and 
      Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research 
      Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 
      Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and 
      Daniel.Blumberger@camh.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160525
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Biophysics
MH  - Brain Mapping
MH  - Electric Stimulation
MH  - *Electroencephalography
MH  - Evoked Potentials/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/physiology
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Reaction Time/*physiology
MH  - Statistics as Topic
MH  - *Transcranial Magnetic Stimulation
MH  - Young Adult
PMC - PMC5009207
OTO - NOTNLM
OT  - TMS-evoked potentials
OT  - combined TMS-EEG study
OT  - dorsolateral prefrontal cortex
OT  - short-latency afferent inhibition
EDAT- 2016/05/27 06:00
MHDA- 2017/09/09 06:00
PMCR- 2017/09/01
CRDT- 2016/05/27 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2016/06/02 00:00 [accepted]
PHST- 2016/05/27 06:00 [entrez]
PHST- 2016/05/27 06:00 [pubmed]
PHST- 2017/09/09 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - jn.00260.2016 [pii]
AID - JN-00260-2016 [pii]
AID - 10.1152/jn.00260.2016 [doi]
PST - ppublish
SO  - J Neurophysiol. 2016 Sep 1;116(3):938-48. doi: 10.1152/jn.00260.2016. Epub 2016 
      May 25.