PMID- 27227027
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160526
LR  - 20200929
IS  - 2332-8940 (Print)
IS  - 2332-8959 (Electronic)
IS  - 2332-8940 (Linking)
VI  - 2
IP  - 2
DP  - 2015 Apr-Jun
TI  - Induction of therapeutic hypothermia by pharmacological modulation of 
      temperature-sensitive TRP channels: theoretical framework and practical 
      considerations.
PG  - 244-57
LID - 10.1080/23328940.2015.1024383 [doi]
AB  - Therapeutic hypothermia has emerged as a remarkably effective method of 
      neuroprotection from ischemia and is being increasingly used in clinics. 
      Accordingly, it is also a subject of considerable attention from a basic 
      scientific research perspective. One of the fundamental problems, with which 
      current studies are concerned, is the optimal method of inducing hypothermia. 
      This review seeks to provide a broad theoretical framework for approaching this 
      problem, and to discuss how a novel promising strategy of pharmacological 
      modulation of the thermosensitive ion channels fits into this framework. Various 
      physical, anatomical, physiological and molecular aspects of thermoregulation, 
      which provide the foundation for this text, have been comprehensively reviewed 
      and will not be discussed exhaustively here. Instead, the first part of the 
      current review, which may be helpful for a broader readership outside of 
      thermoregulation research, will build on this existing knowledge to outline 
      possible opportunities and research directions aimed at controlling body 
      temperature. The second part, aimed at a more specialist audience, will highlight 
      the conceptual advantages and practical limitations of novel molecular agents 
      targeting thermosensitive Transient Receptor Potential (TRP) channels in 
      achieving this goal. Two particularly promising members of this channel family, 
      namely TRP melastatin 8 (TRPM8) and TRP vanilloid 1 (TRPV1), will be discussed in 
      greater detail.
FAU - Feketa, Viktor V
AU  - Feketa VV
AD  - Department of Molecular Physiology and Biophysics Graduate Program; 
      Cardiovascular Sciences Track; Baylor College of Medicine , Houston, TX, USA.
FAU - Marrelli, Sean P
AU  - Marrelli SP
AD  - Department of Molecular Physiology and Biophysics Graduate Program; 
      Cardiovascular Sciences Track; Baylor College of Medicine, Houston, TX, USA; 
      Department of Anesthesiology; Baylor College of Medicine, Houston, TX, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150427
PL  - United States
TA  - Temperature (Austin)
JT  - Temperature (Austin, Tex.)
JID - 101655855
PMC - PMC4844121
OTO - NOTNLM
OT  - DMH, dorso-medial hypothalamus
OT  - MPA, medial preoptic area of hypothalamus
OT  - TRP, Transient Receptor Potential
OT  - TRPA1, Transient Receptor Potential cation channel, subfamily A, member 1
OT  - TRPM8, Transient Receptor Potential cation channel, subfamily M, member 8
OT  - TRPV1, Transient Receptor Potential cation channel, subfamily V, member 1
OT  - TRPV2, Transient Receptor Potential cation channel, subfamily V, member 2
OT  - TRPV3, Transient Receptor Potential cation channel, subfamily V, member 3
OT  - TRPV4, Transient Receptor Potential cation channel, subfamily V, member 4
OT  - ThermoTRPs
OT  - ThermoTRPs, Thermosensitive Transient Receptor Potential cation channels
OT  - body temperature
OT  - core temperature
OT  - pharmacological hypothermia
OT  - physical cooling
OT  - rMR, rostral medullary raphe region
OT  - therapeutic hypothermia
OT  - thermopharmacology
OT  - thermoregulation
OT  - thermosensitive ion channels
EDAT- 2016/05/27 06:00
MHDA- 2016/05/27 06:01
PMCR- 2015/04/27
CRDT- 2016/05/27 06:00
PHST- 2014/12/03 00:00 [received]
PHST- 2015/02/25 00:00 [revised]
PHST- 2015/02/25 00:00 [accepted]
PHST- 2016/05/27 06:00 [entrez]
PHST- 2016/05/27 06:00 [pubmed]
PHST- 2016/05/27 06:01 [medline]
PHST- 2015/04/27 00:00 [pmc-release]
AID - 1024383 [pii]
AID - 10.1080/23328940.2015.1024383 [doi]
PST - epublish
SO  - Temperature (Austin). 2015 Apr 27;2(2):244-57. doi: 
      10.1080/23328940.2015.1024383. eCollection 2015 Apr-Jun.