PMID- 27229324
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20181202
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 May 27
TI  - The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for 
      Immunological Tolerance during Pregnancy in the Mouse.
PG  - 26984
LID - 10.1038/srep26984 [doi]
LID - 26984
AB  - Dendritic cells (DCs), which can shape their functions depending on the 
      microenvironment, are crucial for the delicate balance of immunity and tolerance 
      during pregnancy. However, the mechanism underlying the microenvironment-educated 
      plasticity of DC differentiation during pregnancy remains largely unclear. Here, 
      we found that the differentiation of conventional DCs (cDCs) and plasmacytoid DCs 
      (pDCs) is regulated in a tissue-specific manner during pregnancy. The ratio of 
      cDCs and pDCs remained constant in the spleen. However, the ratio changed in the 
      para-aortic lymph nodes (LNs), where cDC percentages were significantly reduced 
      concurrent with an increase in pDCs from E8.5 to E16.5. Moreover, the expansion 
      of pDCs and T regulatory (Treg) cells was correlated in the para-aortic LNs, and 
      pDCs had more potential to induce regulatory T cells (Tregs) compared with cDCs 
      (independent of IDO expression). Notably, the balance between cDCs and pDCs is 
      disrupted in IFN-gamma-induced abnormal pregnancy, accompanied by lower Treg 
      percentages in the para-aortic LNs and decidua. To further identify the 
      underlying mechanism, we found that elevated IFN-gamma can increase the levels of 
      GM-CSF to alter the differentiation of pDCs into cDCs in vivo. Therefore, we 
      provide a novel regulatory mechanism underlying pregnancy-related immune 
      tolerance that involves the balance of DC subsets, which may offer a new target 
      for the prevention of human spontaneous abortion.
FAU - Fang, Wen-Ning
AU  - Fang WN
AD  - State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, People's Republic of China.
AD  - University of Chinese Academy of Sciences, Beijing, People's Republic of China.
FAU - Shi, Meng
AU  - Shi M
AD  - School of Biological Sciences, Nanyang Technological University, Singapore.
FAU - Meng, Chao-Yang
AU  - Meng CY
AD  - State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, People's Republic of China.
AD  - University of Chinese Academy of Sciences, Beijing, People's Republic of China.
FAU - Li, Dan-Dan
AU  - Li DD
AD  - State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, People's Republic of China.
AD  - University of Chinese Academy of Sciences, Beijing, People's Republic of China.
FAU - Peng, Jing-Pian
AU  - Peng JP
AD  - State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160527
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Aorta/cytology/drug effects/immunology
MH  - Cell Differentiation/drug effects
MH  - Decidua/cytology/*drug effects/immunology
MH  - Dendritic Cells/cytology/*drug effects/immunology
MH  - Embryo, Mammalian
MH  - Female
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/immunology/metabolism
MH  - Humans
MH  - Immune Tolerance/*drug effects
MH  - Interferon-gamma/*pharmacology
MH  - Lymph Nodes/cytology/*drug effects/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Organ Specificity
MH  - Pregnancy
MH  - Spleen/cytology/*drug effects/immunology
MH  - T-Lymphocytes, Regulatory/cytology/drug effects/immunology
PMC - PMC4882543
EDAT- 2016/05/28 06:00
MHDA- 2018/05/16 06:00
PMCR- 2016/05/27
CRDT- 2016/05/28 06:00
PHST- 2016/01/19 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/05/28 06:00 [entrez]
PHST- 2016/05/28 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2016/05/27 00:00 [pmc-release]
AID - srep26984 [pii]
AID - 10.1038/srep26984 [doi]
PST - epublish
SO  - Sci Rep. 2016 May 27;6:26984. doi: 10.1038/srep26984.