PMID- 27229720
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 22
IP  - 28
DP  - 2016
TI  - DNA Methylation: An Epigenetic Insight into Type 2 Diabetes Mellitus.
PG  - 4398-419
AB  - DNA methylation, a major regulator of epigenetic modifications has been shown to 
      alter the expression of genes that are involved in aspects of glucose metabolism 
      such as glucose intolerance, insulin resistance, beta-cell dysfunction and other 
      conditions, and it ultimately leads to the pathogenesis of type 2 diabetes 
      mellitus (T2DM). Current evidences indicate an association of DNA methylation 
      with T2DM. This review provides an overview of how various factors play crucial 
      roles in T2DM pathogenesis and how DNA methylation interacts with these factors. 
      Additionally, an update on current techniques of DNA methylation analysis with 
      their pros and cons is provided as a basis for the adoption of suitable 
      techniques in future DNA methylation research towards better management of T2DM. 
      To elucidate the mechanistic relationship between vital environmental factors and 
      the development of T2DM, a better understanding of the changes in gene expression 
      associated with DNA methylation at the molecular level is still needed.
FAU - Alam, Fahmida
AU  - Alam F
FAU - Islam, Md Asiful
AU  - Islam MA
FAU - Gan, Siew Hua
AU  - Gan SH
FAU - Mohamed, Mafauzy
AU  - Mohamed M
FAU - Sasongko, Teguh Haryo
AU  - Sasongko TH
AD  - Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 
      Kubang Kerian, Kelantan, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Animals
MH  - *DNA Methylation
MH  - Diabetes Mellitus, Type 2/*genetics/physiopathology
MH  - Disease Models, Animal
MH  - *Epigenesis, Genetic
MH  - Humans
MH  - Risk Factors
EDAT- 2016/05/28 06:00
MHDA- 2018/03/10 06:00
CRDT- 2016/05/28 06:00
PHST- 2016/04/23 00:00 [received]
PHST- 2016/05/26 00:00 [accepted]
PHST- 2016/05/28 06:00 [entrez]
PHST- 2016/05/28 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - CPD-EPUB-75984 [pii]
AID - 10.2174/1381612822666160527111152 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2016;22(28):4398-419. doi: 10.2174/1381612822666160527111152.