PMID- 27230861
OWN - NLM
STAT- MEDLINE
DCOM- 20170307
LR  - 20220411
IS  - 1423-0348 (Electronic)
IS  - 0033-3190 (Linking)
VI  - 85
IP  - 4
DP  - 2016
TI  - Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive 
      Impairment: A Randomized Controlled Trial.
PG  - 198-207
LID - 10.1159/000442261 [doi]
AB  - BACKGROUND: We examined the efficacy of group-based cognitive intervention (GCI) 
      and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment 
      (aMCI) and intervention effects on serum brain-derived neurotrophic factor 
      (BDNF). METHODS: In this randomized and rater-blinded trial, 293 patients with 
      aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the 
      HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI 
      participated twice per week in group sessions led by trained instructors, and 
      those receiving HCI completed homework materials 5 days per week. They were 
      assessed at baseline, postintervention (PI) and at the 6-month follow-up after 
      the intervention. The primary endpoint was the change from baseline to PI in the 
      modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). 
      RESULTS: In comparison to the controls (a 0.8-point decrease), the subjects 
      receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 
      0.02) showed significant improvements in the modified ADAS-Cog at PI, 
      respectively. By the 6-month follow-up, those receiving GCI or HCI had better 
      scores in the modified ADAS-Cog than the controls. The changes in BDNF levels 
      significantly correlated with the changes in the modified ADAS-Cog in the GCI (r 
      = -0.29, p = 0.02 at PI) and HCI (r = -0.27, p = 0.03 at 6-month follow-up) 
      groups, respectively. CONCLUSIONS: The GCI and HCI resulted in cognitive 
      improvements in aMCI. An enhanced brain plasticity may be a component of the 
      mechanism underpinning the cognitive improvements associated with the cognitive 
      interventions.
CI  - (c) 2016 The Author(s) Published by S. Karger AG, Basel.
FAU - Jeong, Jee Hyang
AU  - Jeong JH
AD  - Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans 
      University School of Medicine, Seoul, South Korea.
FAU - Na, Hae Ri
AU  - Na HR
FAU - Choi, Seong Hye
AU  - Choi SH
FAU - Kim, Jungeun
AU  - Kim J
FAU - Na, Duk L
AU  - Na DL
FAU - Seo, Sang Won
AU  - Seo SW
FAU - Chin, Juhee
AU  - Chin J
FAU - Park, Sun Ah
AU  - Park SA
FAU - Kim, Eun-Joo
AU  - Kim EJ
FAU - Han, Hyun Jeong
AU  - Han HJ
FAU - Han, Seol-Heui
AU  - Han SH
FAU - Yoon, Soo Jin
AU  - Yoon SJ
FAU - Lee, Jae-Hong
AU  - Lee JH
FAU - Park, Kyung Won
AU  - Park KW
FAU - Moon, So Young
AU  - Moon SY
FAU - Park, Moon Ho
AU  - Park MH
FAU - Choi, Mun Seong
AU  - Choi MS
FAU - Han, Il-Woo
AU  - Han IW
FAU - Lee, Jun Hong
AU  - Lee JH
FAU - Lee, Jung Seok
AU  - Lee JS
FAU - Shim, Yong S
AU  - Shim YS
FAU - Kim, Jeong Yeon
AU  - Kim JY
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20160527
PL  - Switzerland
TA  - Psychother Psychosom
JT  - Psychotherapy and psychosomatics
JID - 0024046
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amnesia/*therapy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition
MH  - Cognitive Behavioral Therapy/*methods/standards
MH  - Cognitive Dysfunction/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Psychotherapy, Group/*methods
MH  - Republic of Korea
MH  - Self Care/*methods
MH  - Single-Blind Method
MH  - Treatment Outcome
EDAT- 2016/05/28 06:00
MHDA- 2017/03/08 06:00
CRDT- 2016/05/28 06:00
PHST- 2015/05/15 00:00 [received]
PHST- 2015/11/06 00:00 [accepted]
PHST- 2016/05/28 06:00 [entrez]
PHST- 2016/05/28 06:00 [pubmed]
PHST- 2017/03/08 06:00 [medline]
AID - 000442261 [pii]
AID - 10.1159/000442261 [doi]
PST - ppublish
SO  - Psychother Psychosom. 2016;85(4):198-207. doi: 10.1159/000442261. Epub 2016 May 
      27.