PMID- 27231174
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20221207
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 129
IP  - 11
DP  - 2016 Jun 5
TI  - Associations of Human Leukocyte Antigen-DRB1 Alleles with Nasopharyngeal 
      Carcinoma and Its Clinical Significance in Xinjiang Uyghur Autonomous Region of 
      China.
PG  - 1347-54
LID - 10.4103/0366-6999.182833 [doi]
AB  - BACKGROUND: Genetic susceptibility is one of the major etiological factors for 
      nasopharyngeal carcinoma (NPC). Among the genetic predisposing factors, human 
      leukocyte antigen (HLA) genes have been reported to be associated with NPC. This 
      study aimed to investigate the associations of HLA-DRB1 alleles with NPC and the 
      clinical significance of HLA-DRB1 alleles in NPC. METHODS: From January 2009 to 
      December 2013, 140 NPC patients (118 Han patients and 22 Uyghur patients) and 158 
      healthy controls (81 Han individuals and 77 Uyghur individuals) from Xinjiang 
      Province were genotyped for HLA-DRB1 using the polymerase chain reaction-sequence 
      specific primer technique. Chi-square analysis was used when comparing allele 
      frequencies between groups. The clinical outcomes were evaluated by Kaplan-Meier 
      method and Cox regression model. RESULTS: Compared with healthy controls, the 
      allele frequency of HLA-DRB1*0701 was increased in the Uyghur patients (P = 
      0.008) but not in the Han patients (P = 0.869). HLA-DRB1*0101 allele was 
      presented with higher frequency in clinical Stage I + II group compared with 
      clinical Stage III + IV group in the Han patients (P = 0.015) but not in the 
      Uyghur patients (P = 1.000). Higher frequency of HLA-DRB1*1501 allele was 
      observed in patients aged <45 years compared with those in patients aged >/=45 
      years (P = 0.002). Neither HLA-DRB1*0701 nor HLA-DRB1*0101 had a statistically 
      significant association with 3-year survival. CONCLUSIONS: This study found 
      HLA-DRB1*0701 in Uyghur population was associated with an increased risk of 
      developing NPC. In Han population, we found HLA-DRB1*0101 was associated with 
      protection from disease progression, and HLA-DRB1*1501 was associated with early 
      age of onset. HLA-DRB1 could not be identified as a prognostic indicator for NPC 
      in either Han or Uyghur patients.
FAU - Geng, Xiao-Tao
AU  - Geng XT
AD  - Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Hu, Yun-Hui
AU  - Hu YH
AD  - Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Dong, Tao
AU  - Dong T
AD  - MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford 
      University, Oxford OX3 9DS, UK.
FAU - Wang, Ruo-Zheng
AU  - Wang RZ
AD  - Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000; Xinjiang Key Laboratory of Oncology, 
      The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 
      830000, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Carcinoma
MH  - China
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*genetics/*pathology
MH  - Polymorphism, Genetic/genetics
MH  - Prognosis
PMC - PMC4894047
EDAT- 2016/05/28 06:00
MHDA- 2017/03/14 06:00
PMCR- 2016/06/05
CRDT- 2016/05/28 06:00
PHST- 2016/05/28 06:00 [entrez]
PHST- 2016/05/28 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/06/05 00:00 [pmc-release]
AID - ChinMedJ_2016_129_11_1347_182833 [pii]
AID - CMJ-129-1347 [pii]
AID - 10.4103/0366-6999.182833 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2016 Jun 5;129(11):1347-54. doi: 10.4103/0366-6999.182833.