PMID- 27231932
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20211204
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 8
IP  - 6
DP  - 2016 May 24
TI  - Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
LID - 10.3390/v8060152 [doi]
LID - 152
AB  - The mammalian target of rapamycin (mTOR) is a central regulator of gene 
      expression, translation and various metabolic processes. Multiple extracellular 
      (growth factors) and intracellular (energy status) molecular signals as well as a 
      variety of stressors are integrated into the mTOR pathway. Viral infection is a 
      significant stress that can activate, reduce or even suppress the mTOR signaling 
      pathway. Consequently, viruses have evolved a plethora of different mechanisms to 
      attack and co-opt the mTOR pathway in order to make the host cell a hospitable 
      environment for replication. A more comprehensive knowledge of different viral 
      interactions may provide fruitful targets for new antiviral drugs.
FAU - Le Sage, Valerie
AU  - Le Sage V
AD  - HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General 
      Hospital, Montreal, QC H3T 1E2, Canada. vle_sage@hotmail.com.
FAU - Cinti, Alessandro
AU  - Cinti A
AD  - HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General 
      Hospital, Montreal, QC H3T 1E2, Canada. alessandro.cinti@mail.mcgill.ca.
AD  - Department of Medicine, McGill University, Montreal, QC H3A 0G4, Canada. 
      alessandro.cinti@mail.mcgill.ca.
FAU - Amorim, Raquel
AU  - Amorim R
AD  - HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General 
      Hospital, Montreal, QC H3T 1E2, Canada. raquel.amorim@mail.mcgill.ca.
AD  - Department of Medicine, McGill University, Montreal, QC H3A 0G4, Canada. 
      raquel.amorim@mail.mcgill.ca.
FAU - Mouland, Andrew J
AU  - Mouland AJ
AD  - HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General 
      Hospital, Montreal, QC H3T 1E2, Canada. andrew.mouland@mcgill.ca.
AD  - Department of Medicine, McGill University, Montreal, QC H3A 0G4, Canada. 
      andrew.mouland@mcgill.ca.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Review
DEP - 20160524
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - DNA Viruses/pathogenicity/*physiology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - RNA Viruses/pathogenicity/*physiology
MH  - *Signal Transduction
MH  - *Stress, Physiological
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - *Virus Replication
PMC - PMC4926172
OTO - NOTNLM
OT  - 4EBP1
OT  - Akt
OT  - PI3K
OT  - autophagy
OT  - mTOR
OT  - virus
EDAT- 2016/05/28 06:00
MHDA- 2017/09/14 06:00
PMCR- 2016/06/01
CRDT- 2016/05/28 06:00
PHST- 2016/04/28 00:00 [received]
PHST- 2016/05/16 00:00 [revised]
PHST- 2016/05/19 00:00 [accepted]
PHST- 2016/05/28 06:00 [entrez]
PHST- 2016/05/28 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - v8060152 [pii]
AID - viruses-08-00152 [pii]
AID - 10.3390/v8060152 [doi]
PST - epublish
SO  - Viruses. 2016 May 24;8(6):152. doi: 10.3390/v8060152.